Effects of oral administration of a commercial activated charcoal suspension on serum osmolality and lactate concentration in the dog

Jamie Burkitt Creedon, Steve C. Haskins, Janet Aldrich, Karl Jandrey, Marlis L. Rezende, Jennifer E. Boyle

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The purpose of this investigation was to determine the effects of an activated charcoal (AC) suspension containing propylene glycol and glycerol on serum osmolality, osmolal gap, and lactate concentration in dogs. Six healthy adult dogs were administered 4 g/kg AC in a commercially available suspension that contained propylene glycol and glycerol as vehicles. Blood samples were taken before and 1, 4, 6, 8, 12, and 24 hours after the administration of the test suspension. Samples were analyzed for osmolality, blood gases, and concentrations of lactate, sodium, potassium, serum urea nitrogen, and glucose. Osmolal gaps were calculated for each time point. Mean serum osmolality, osmolal gap, and lactate concentration were significantly increased after suspension administration compared to baseline. Serum osmolality increased from 311 mOsm/kg at baseline to 353 mOsm/kg, osmolal gap increased from 5 to 52 mOsm/kg, and lactate concentration increased from 1.9 to 4.5 mmol/L after suspension administration (all P < .01). Three of the 6 dogs vomited between 1 and 3 hours after the administration of the test suspension, and 4 of 6 dogs were lethargic. All dogs drank frequently after AC administration. Commercial AC suspension administered at a clinically relevant dose increases serum osmolality, osmolal gap, and lactate concentration in dogs. These laboratory measures and the clinical signs of vomiting, lethargy, and increased frequency of drinking might complicate the diagnosis or monitoring of some intoxications (such as ethylene glycol) in dogs that have previously received AC suspension containing propylene glycol, glycerol, or both as vehicles.

Original languageEnglish (US)
Pages (from-to)683-686
Number of pages4
JournalJournal of Veterinary Internal Medicine
Volume19
Issue number5
DOIs
StatePublished - Sep 2005

Fingerprint

Charcoal
osmolality
activated carbon
blood serum
Osmolar Concentration
oral administration
lactates
Oral Administration
Lactic Acid
Suspensions
Dogs
dogs
Serum
Propylene Glycol
propylene glycol
Glycerol
glycerol
Sodium Lactate
Lethargy
Ethylene Glycol

Keywords

  • Decontamination
  • Hyperlactatemia
  • Hyperosmolality
  • Osmolal gap
  • Toxicity

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of oral administration of a commercial activated charcoal suspension on serum osmolality and lactate concentration in the dog. / Burkitt Creedon, Jamie; Haskins, Steve C.; Aldrich, Janet; Jandrey, Karl; Rezende, Marlis L.; Boyle, Jennifer E.

In: Journal of Veterinary Internal Medicine, Vol. 19, No. 5, 09.2005, p. 683-686.

Research output: Contribution to journalArticle

Burkitt Creedon, Jamie ; Haskins, Steve C. ; Aldrich, Janet ; Jandrey, Karl ; Rezende, Marlis L. ; Boyle, Jennifer E. / Effects of oral administration of a commercial activated charcoal suspension on serum osmolality and lactate concentration in the dog. In: Journal of Veterinary Internal Medicine. 2005 ; Vol. 19, No. 5. pp. 683-686.
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