Effects of oleic acid-induced lung injury on oxygen transport and aerobic capacity

George H. Crocker, James H Jones

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

We tested the hypothesis that oleic-acid (OA) infusion impairs gas exchange, decreases total cardiopulmonary O2 delivery and lowers maximal aerobic capacity (V̇O2max). We infused 0.05ml OAkg-1 (~3ml) and ~563ml saline into the right atria of four goats [59.1±14.0 (SD) kg] prior to running them on a treadmill at V̇O2max 2-h and 1-d following OA-induced acute lung injury, and with no lung injury. Acute lung injury decreased V̇O2max, O2 delivery, arterial O2 concentration and arterial O2 partial pressure compared to no lung injury. The V̇O2max positively correlated with O2 delivery and inversely correlated with alveolar-arterial O2 partial pressure difference, suggesting that impaired pulmonary gas exchange decreased O2 delivery and uptake. Results indicate OA infusion may be a useful model for acutely impairing pulmonary gas exchange for exercise studies. Seven OA infusions induced smaller chronic gas exchange and arterial O2 partial pressure changes than acute infusion.

Original languageEnglish (US)
Pages (from-to)43-49
Number of pages7
JournalRespiratory Physiology and Neurobiology
Volume196
Issue number1
DOIs
StatePublished - Jun 1 2014

Keywords

  • Diffusion impairment
  • Exercise
  • Goat
  • Lung injury

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)
  • Medicine(all)

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