Effects of oleic acid-induced lung injury on oxygen transport and aerobic capacity

George H. Crocker; James H Jones

doi:10.1016/j.resp.2014.02.012

Effects of oleic acid-induced lung injury on oxygen transport and aerobic capacity

George H. Crocker, James H Jones

Surgical and Radiological Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We tested the hypothesis that oleic-acid (OA) infusion impairs gas exchange, decreases total cardiopulmonary O₂ delivery and lowers maximal aerobic capacity (V̇O2max). We infused 0.05ml OAkg^-1 (~3ml) and ~563ml saline into the right atria of four goats [59.1±14.0 (SD) kg] prior to running them on a treadmill at V̇O2max 2-h and 1-d following OA-induced acute lung injury, and with no lung injury. Acute lung injury decreased V̇O2max, O₂ delivery, arterial O₂ concentration and arterial O₂ partial pressure compared to no lung injury. The V̇O2max positively correlated with O₂ delivery and inversely correlated with alveolar-arterial O₂ partial pressure difference, suggesting that impaired pulmonary gas exchange decreased O₂ delivery and uptake. Results indicate OA infusion may be a useful model for acutely impairing pulmonary gas exchange for exercise studies. Seven OA infusions induced smaller chronic gas exchange and arterial O₂ partial pressure changes than acute infusion.

Original language	English (US)
Pages (from-to)	43-49
Number of pages	7
Journal	Respiratory Physiology and Neurobiology
Volume	196
Issue number	1
DOIs	https://doi.org/10.1016/j.resp.2014.02.012
State	Published - Jun 1 2014

Keywords

Diffusion impairment
Exercise
Goat
Lung injury

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine
Neuroscience(all)
Medicine(all)

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title = "Effects of oleic acid-induced lung injury on oxygen transport and aerobic capacity",

abstract = "We tested the hypothesis that oleic-acid (OA) infusion impairs gas exchange, decreases total cardiopulmonary O2 delivery and lowers maximal aerobic capacity ({\.V}O2max). We infused 0.05ml OAkg-1 (~3ml) and ~563ml saline into the right atria of four goats [59.1±14.0 (SD) kg] prior to running them on a treadmill at {\.V}O2max 2-h and 1-d following OA-induced acute lung injury, and with no lung injury. Acute lung injury decreased {\.V}O2max, O2 delivery, arterial O2 concentration and arterial O2 partial pressure compared to no lung injury. The {\.V}O2max positively correlated with O2 delivery and inversely correlated with alveolar-arterial O2 partial pressure difference, suggesting that impaired pulmonary gas exchange decreased O2 delivery and uptake. Results indicate OA infusion may be a useful model for acutely impairing pulmonary gas exchange for exercise studies. Seven OA infusions induced smaller chronic gas exchange and arterial O2 partial pressure changes than acute infusion.",

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