Effects of Mu opioid agonist and antagonist on neurological outcome following traumatic brain injury in the rat

Bruce G Lyeth, J. Y. Jiang, Q. Z. Gong, R. J. Hamm, H. F. Young

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We examined the effects of an exogenous mu opioid agonist and antagonist on systemic physiology and neurological outcome following TBI in the rat. Experiment I: [D-Ala2,NMe-Phe4,Gly5-ol]-enkephalin (DAMGO) (0.1 nMol or 0.3 nMol in 5μl) (n = 10) or artificial CSF (n = 10) was administered 5 min prior to fluid-percussion brain injury (2.1 atmospheres). Motor performance was assessed on days 1-5 after TBI. The mu receptor agonist, DAMGO significantly reduced both beam-walking latency and body weight loss after injury (p < 0.05). DAMGO-treated rats (n = 5) did not differ from CSF-treated rats (n = 5) on either systemic arterial blood pressure or heart rate responses to injury. Experiment II: Beta-funaltrexamine (β-FNA) (20.0 nMol in 5.0 μl) (n = 10) or artificial CSF (n = 10) was administered (icv) to rats 5 min prior to fluid-percussion brain injury (1.8 atmospheres). Motor performance was assessed on days 1-5 after TBI. The mu receptor antagonist, β-FNA, significantly increased beam-walking latency after injury (p < 0.05). β-FNA-treated rats (n = 5) did not differ from CSF-treated rats (n = 5) on either systemic arterial blood pressure or heart rate responses to injury. Experiment III: Neither β-FNA nor DAMGO affected motor performance in uninjured rats. These results suggest that activation of mu opioid receptors by exogenous agonists may provide protection against deficits in motor performance produced by fluid percussion brain injury.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalNeuropeptides
Volume29
Issue number1
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology
  • Cellular and Molecular Neuroscience
  • Endocrine and Autonomic Systems
  • Neurology
  • Clinical Neurology
  • Endocrinology, Diabetes and Metabolism
  • Neuroscience(all)
  • Biochemistry

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