Effects of methyllycaconitine and related analogues on bovine adrenal α3β4* nicotinic acetylcholine receptors

Darrell L. Bryant, R. Benjamin Free, Sara M Thomasy, David J. Lapinsky, K. A. Ismail, K. M. Arason, Stephen C. Bergmeier, Dennis B. McKay

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal α3β4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.

Original languageEnglish (US)
Pages (from-to)139-141
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume971
StatePublished - Jun 5 2002
Externally publishedYes

Fingerprint

Nicotinic Receptors
methyllycaconitine
Secretion

Keywords

  • Adrenal α3β4 nicotinic acetylcholine receptors
  • Methyllycaconitine
  • MLA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Bryant, D. L., Free, R. B., Thomasy, S. M., Lapinsky, D. J., Ismail, K. A., Arason, K. M., ... McKay, D. B. (2002). Effects of methyllycaconitine and related analogues on bovine adrenal α3β4* nicotinic acetylcholine receptors. Annals of the New York Academy of Sciences, 971, 139-141.

Effects of methyllycaconitine and related analogues on bovine adrenal α3β4* nicotinic acetylcholine receptors. / Bryant, Darrell L.; Free, R. Benjamin; Thomasy, Sara M; Lapinsky, David J.; Ismail, K. A.; Arason, K. M.; Bergmeier, Stephen C.; McKay, Dennis B.

In: Annals of the New York Academy of Sciences, Vol. 971, 05.06.2002, p. 139-141.

Research output: Contribution to journalArticle

Bryant, DL, Free, RB, Thomasy, SM, Lapinsky, DJ, Ismail, KA, Arason, KM, Bergmeier, SC & McKay, DB 2002, 'Effects of methyllycaconitine and related analogues on bovine adrenal α3β4* nicotinic acetylcholine receptors', Annals of the New York Academy of Sciences, vol. 971, pp. 139-141.
Bryant, Darrell L. ; Free, R. Benjamin ; Thomasy, Sara M ; Lapinsky, David J. ; Ismail, K. A. ; Arason, K. M. ; Bergmeier, Stephen C. ; McKay, Dennis B. / Effects of methyllycaconitine and related analogues on bovine adrenal α3β4* nicotinic acetylcholine receptors. In: Annals of the New York Academy of Sciences. 2002 ; Vol. 971. pp. 139-141.
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