Effects of methyllycaconitine and related analogues on bovine adrenal α3β4* nicotinic acetylcholine receptors

Darrell L. Bryant, R. Benjamin Free, Sara M Thomasy, David J. Lapinsky, K. A. Ismail, K. M. Arason, Stephen C. Bergmeier, Dennis B. McKay

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Adrenal secretion and binding studies were performed using ring E analogues of methyllycaconitine to assess structural determinants affecting activity on bovine adrenal α3β4* nicotinic receptors. The most potent analogues are as potent as many inhibitors of adrenal secretion. Our data support the potential use of methyllycaconitine analogues to generate nicotinic receptor subtype-specific compounds.

Original languageEnglish (US)
Pages (from-to)139-141
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume971
StatePublished - Jun 5 2002
Externally publishedYes

Keywords

  • Adrenal α3β4 nicotinic acetylcholine receptors
  • Methyllycaconitine
  • MLA

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Bryant, D. L., Free, R. B., Thomasy, S. M., Lapinsky, D. J., Ismail, K. A., Arason, K. M., Bergmeier, S. C., & McKay, D. B. (2002). Effects of methyllycaconitine and related analogues on bovine adrenal α3β4* nicotinic acetylcholine receptors. Annals of the New York Academy of Sciences, 971, 139-141.