Effects of metformin on hepatic glucose metabolism

Mark P. Christiansen, Marc K. Hellerstein

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Metformin, dimethylbiguanide, is an agent that has been widely used in the treatment of non-insulin-dependent diabetes mellitus. Its mechanism of action is not dependent on the stimulation of insulin secretion, unlike the sulfonylureas. It is clear that metformin reduces fasting endogenous glucose production rates, which are elevated in non-insulin-dependent diabetes mellitus. Some studies have proposed that metformin reduces endogenous glucose production primarily by reducing gluconeogenesis, whereas others have proposed that gluconeogenesis is not affected. The authors review the literature regarding the effects of metformin on hepatic carbohydrate metabolism.

Original languageEnglish (US)
Pages (from-to)252-255
Number of pages4
JournalCurrent Opinion in Endocrinology and Diabetes
Volume5
Issue number4
StatePublished - 1998

Fingerprint

Metformin
Glucose
Gluconeogenesis
Liver
Type 2 Diabetes Mellitus
Carbohydrate Metabolism
Fasting
Insulin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Christiansen, M. P., & Hellerstein, M. K. (1998). Effects of metformin on hepatic glucose metabolism. Current Opinion in Endocrinology and Diabetes, 5(4), 252-255.

Effects of metformin on hepatic glucose metabolism. / Christiansen, Mark P.; Hellerstein, Marc K.

In: Current Opinion in Endocrinology and Diabetes, Vol. 5, No. 4, 1998, p. 252-255.

Research output: Contribution to journalArticle

Christiansen, MP & Hellerstein, MK 1998, 'Effects of metformin on hepatic glucose metabolism', Current Opinion in Endocrinology and Diabetes, vol. 5, no. 4, pp. 252-255.
Christiansen, Mark P. ; Hellerstein, Marc K. / Effects of metformin on hepatic glucose metabolism. In: Current Opinion in Endocrinology and Diabetes. 1998 ; Vol. 5, No. 4. pp. 252-255.
@article{75f0d5e018d04429b866bc424024af0a,
title = "Effects of metformin on hepatic glucose metabolism",
abstract = "Metformin, dimethylbiguanide, is an agent that has been widely used in the treatment of non-insulin-dependent diabetes mellitus. Its mechanism of action is not dependent on the stimulation of insulin secretion, unlike the sulfonylureas. It is clear that metformin reduces fasting endogenous glucose production rates, which are elevated in non-insulin-dependent diabetes mellitus. Some studies have proposed that metformin reduces endogenous glucose production primarily by reducing gluconeogenesis, whereas others have proposed that gluconeogenesis is not affected. The authors review the literature regarding the effects of metformin on hepatic carbohydrate metabolism.",
author = "Christiansen, {Mark P.} and Hellerstein, {Marc K.}",
year = "1998",
language = "English (US)",
volume = "5",
pages = "252--255",
journal = "Current Opinion in Endocrinology, Diabetes and Obesity",
issn = "1752-296X",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Effects of metformin on hepatic glucose metabolism

AU - Christiansen, Mark P.

AU - Hellerstein, Marc K.

PY - 1998

Y1 - 1998

N2 - Metformin, dimethylbiguanide, is an agent that has been widely used in the treatment of non-insulin-dependent diabetes mellitus. Its mechanism of action is not dependent on the stimulation of insulin secretion, unlike the sulfonylureas. It is clear that metformin reduces fasting endogenous glucose production rates, which are elevated in non-insulin-dependent diabetes mellitus. Some studies have proposed that metformin reduces endogenous glucose production primarily by reducing gluconeogenesis, whereas others have proposed that gluconeogenesis is not affected. The authors review the literature regarding the effects of metformin on hepatic carbohydrate metabolism.

AB - Metformin, dimethylbiguanide, is an agent that has been widely used in the treatment of non-insulin-dependent diabetes mellitus. Its mechanism of action is not dependent on the stimulation of insulin secretion, unlike the sulfonylureas. It is clear that metformin reduces fasting endogenous glucose production rates, which are elevated in non-insulin-dependent diabetes mellitus. Some studies have proposed that metformin reduces endogenous glucose production primarily by reducing gluconeogenesis, whereas others have proposed that gluconeogenesis is not affected. The authors review the literature regarding the effects of metformin on hepatic carbohydrate metabolism.

UR - http://www.scopus.com/inward/record.url?scp=0031742790&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031742790&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031742790

VL - 5

SP - 252

EP - 255

JO - Current Opinion in Endocrinology, Diabetes and Obesity

JF - Current Opinion in Endocrinology, Diabetes and Obesity

SN - 1752-296X

IS - 4

ER -