Effects of memory processing on regional brain activation: Cerebral blood flow in normal subjects

Ruben C. Gur, Jurg L. Jaggi, John D Ragland, Susan M. Resnick, Derri Shtasel, Larry Muenz, Raquel E. Gur

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The role of the temporal lobe in memory has been implicated in lesion studies, which have also suggested the hypothesis of greater left hemispheric involvement in verbal, and right hemispheric involvement in facial memory. We tested these hypotheses in a sample of 27 normal right-handed subjects using the Xenon clearance method for measuring cerebral blood flow (CBF). The CBF was measured during resting baseline, word recognition, and face recognition conditions in counterbalanced order. CBF increased during recognition compared to baseline, and for the midtemporal lobe this increase was asymmetric to the left hemisphere for words and to the right for faces. While overall CBF levels and task related increases in CBF were uncorrelated either with performance or with A performance (excess performance relative to basal memory abilities), laterality of task-related CBF correlated with both performance indices, showing regional specificity of correlations. This neurobehavioral probe paradigm can be applied in the study of neural substrates of normal and disturbed memory.

Original languageEnglish (US)
Pages (from-to)31-44
Number of pages14
JournalInternational Journal of Neuroscience
Volume72
Issue number1-2
DOIs
StatePublished - 1993
Externally publishedYes

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Cerebrovascular Circulation
Brain
Xenon
Aptitude
Temporal Lobe

Keywords

  • Cerebral Blood Flow (CBF)
  • Cortical activity
  • Hemispheric specialization
  • Human performance
  • Memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effects of memory processing on regional brain activation : Cerebral blood flow in normal subjects. / Gur, Ruben C.; Jaggi, Jurg L.; Ragland, John D; Resnick, Susan M.; Shtasel, Derri; Muenz, Larry; Gur, Raquel E.

In: International Journal of Neuroscience, Vol. 72, No. 1-2, 1993, p. 31-44.

Research output: Contribution to journalArticle

Gur, Ruben C. ; Jaggi, Jurg L. ; Ragland, John D ; Resnick, Susan M. ; Shtasel, Derri ; Muenz, Larry ; Gur, Raquel E. / Effects of memory processing on regional brain activation : Cerebral blood flow in normal subjects. In: International Journal of Neuroscience. 1993 ; Vol. 72, No. 1-2. pp. 31-44.
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