Abstract
The activities of two liver gluconeogenic enzymes, pyruvate carboxylase (PC) and phosphoenolpyruvate carboxykinase (PEPCK), as well as liver glycogen and plasma glucose, insulin, and glucagon were measured in first- and second-generation, manganese-sufficient (control) and manganese-deficient (Mn-) adult rats. Pyruvate carboxylase activity of first generation male Mn- rats was higher than that of controls in both the fed and fasted states. In contrast, PC activity in second generation male Mn- rats was lower than control levels. In female rats, PC activity was lower than controls in both fed, first- and second-generation Mn- rats; in the fasted state, PC activity was either the same or higher than controls. Phosphoenolpyruvate carboxykinase activity was lower in male first generation Mn- rats than in controls, but there was no difference in PEPCK activity in second-generation animals. Phosphoenolpyruvate carboxylase activity was lower in both fed and fasted Mn- female rats than in controls. Plasma insulin levels were lower in the deficient rats than in controls, whereas plasma glucagon levels were similar. Manganese-deficient rats had higher concentrations of liver glycogen than their controls. These findings provide further evidence that manganese affects carbohydrate homeostasis; however, the response of the animal to manganese deficiency depends on the parameter studied and the timing of the deficiency.
Original language | English (US) |
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Pages (from-to) | 201-212 |
Number of pages | 12 |
Journal | Biological Trace Element Research |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1986 |
Keywords
- carbohydrate metabolism
- effect of manganese, on gluconeogenic enzymes
- gluconeogenic enzymes
- Manganese
- manganese deficiency
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Biochemistry, Genetics and Molecular Biology(all)
- Biochemistry, medical
- Inorganic Chemistry
- Clinical Biochemistry
- Biochemistry