Effects of long-term intubation on vocal fold mucosa in dogs

Rebecca J Leonard, Craig W Senders, George Charpied

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


A canine model was used to study effects of long-term intubation on vocal fold mucosa. Dogs' larynges were removed 5 weeks after a 7-day intubation period and were compared with control tissue. Intubation effects on vocal fold mucosa were highly variable. Most severe damage was observed posteriorly, at the presumed location of direct tube-mucosa contact. Effects judged to be less severe but still significant were noted in tissue anterior to this site. Morphometric analysis of the layers of the intubated mucosa revealed significant differences in epithelium, connective tissue, and glands, as compared with control tissue. Differences were also observed for blood vessels and nerves. Of particular clinical importance was evidence of damage along membranous, as well as cartilaginous, portions of the true vocal fold, and of damaged connective tissue and cartilage underlying epithelium which appeared normal. Implications of the findings for recovery from intubation, and for voice, are discussed.

Original languageEnglish (US)
Pages (from-to)86-93
Number of pages8
JournalJournal of Voice
Issue number1
StatePublished - 1992


  • Intubation
  • Postintubation hoarseness
  • Vocal fold trauma

ASJC Scopus subject areas

  • Otorhinolaryngology


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