Effects of leflunomide and cyclosporine on myocutaneous allograft survival in the rat

Lih Seng Yeh, Clare R. Gregory, Stephen M Griffey, Richard A Lecouteur, Randall E. Morris

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

The immunosuppressive effects of leflunomide and cyclosporine were evaluated in a rat neurovascularized myocutaneous allograft model. Inbred Brown-Norway and Lewis rats were served as donors and recipients, respectively. All recipients were observed for 60 days or until allograft rejection occurred. All isograft controls (Lewis to Lewis, n=6) survived uneventfully. All control allografts (n=6) were rejected within 6 days. Allograft recipients (n=6) administered leflunomide (10 mg/kg/24 hr) rejected their allografts in 28.50±6.12 days, and allograft recipients (n=6), administered cyclosporine (5 mg/kg/24 hr) rejected their allografts in 24.33±10.48 days. When allograft recipients were administered a combination of leflunomide and cyclosporine (10 mg/kg/24 hr and 5 mg/kg/24 hr, respectively), all allografts survived to 60 days with only partial rejection of the skin of one graft. The neuromuscular function of the allografts of the rats receiving combination therapy was comparable to that of the isografts. The combination of leflunomide and cyclosporine controlled myocutaneous allorejection despite a strong immunological challenge.

Original languageEnglish (US)
Pages (from-to)861-863
Number of pages3
JournalTransplantation
Volume62
Issue number6
StatePublished - Sep 27 1996

ASJC Scopus subject areas

  • Transplantation
  • Immunology

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