Abstract
The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 29-32 |
| Number of pages | 4 |
| Journal | Canadian Veterinary Journal |
| Volume | 40 |
| Issue number | 1 |
| State | Published - 1999 |
| Externally published | Yes |
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ASJC Scopus subject areas
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Cite this
Effects of intravenously administered glycopyrrolate in anesthetized horses. / Dyson, Doris H.; Pascoe, Peter J; McDonell, Wayne N.
In: Canadian Veterinary Journal, Vol. 40, No. 1, 1999, p. 29-32.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of intravenously administered glycopyrrolate in anesthetized horses
AU - Dyson, Doris H.
AU - Pascoe, Peter J
AU - McDonell, Wayne N.
PY - 1999
Y1 - 1999
N2 - The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.
AB - The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.
UR - http://www.scopus.com/inward/record.url?scp=0032953554&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032953554&partnerID=8YFLogxK
M3 - Article
VL - 40
SP - 29
EP - 32
JO - Canadian Veterinary Journal
JF - Canadian Veterinary Journal
SN - 0008-5286
IS - 1
ER -