The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.
|Original language||English (US)|
|Number of pages||4|
|Journal||Canadian Veterinary Journal|
|State||Published - 1999|
ASJC Scopus subject areas