Effects of intravenously administered glycopyrrolate in anesthetized horses

Doris H. Dyson, Peter J Pascoe, Wayne N. McDonell

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.

Original languageEnglish (US)
Pages (from-to)29-32
Number of pages4
JournalCanadian Veterinary Journal
Volume40
Issue number1
StatePublished - 1999
Externally publishedYes

Fingerprint

Glycopyrrolate
Horses
heart rate
Heart Rate
Blood Pressure
horses
blood pressure
Body Weight
body weight
diastolic blood pressure
systolic blood pressure

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of intravenously administered glycopyrrolate in anesthetized horses. / Dyson, Doris H.; Pascoe, Peter J; McDonell, Wayne N.

In: Canadian Veterinary Journal, Vol. 40, No. 1, 1999, p. 29-32.

Research output: Contribution to journalArticle

Dyson, Doris H. ; Pascoe, Peter J ; McDonell, Wayne N. / Effects of intravenously administered glycopyrrolate in anesthetized horses. In: Canadian Veterinary Journal. 1999 ; Vol. 40, No. 1. pp. 29-32.
@article{043760cf7d2648cbb8fdf94af34a8fe0,
title = "Effects of intravenously administered glycopyrrolate in anesthetized horses",
abstract = "The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.",
author = "Dyson, {Doris H.} and Pascoe, {Peter J} and McDonell, {Wayne N.}",
year = "1999",
language = "English (US)",
volume = "40",
pages = "29--32",
journal = "Canadian Veterinary Journal",
issn = "0008-5286",
publisher = "Canadian Veterinary Medical Association",
number = "1",

}

TY - JOUR

T1 - Effects of intravenously administered glycopyrrolate in anesthetized horses

AU - Dyson, Doris H.

AU - Pascoe, Peter J

AU - McDonell, Wayne N.

PY - 1999

Y1 - 1999

N2 - The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.

AB - The purpose of this study was to determine the heart rate (HR) and blood pressure (BP) effect of glycopyrrolate in anesthetized horses with low HR (≤ 30 beats/min). The horses were randomly treated with glycopyrrolate (2.5 μg/kg body weight (BW)) or saline, intravenously (IV) (n = 17). If HR failed to increase (by > 5 beats/min within 10 min), glycopyrrolate (same dose) was administered. Heart rate increased by > 5 beats/min in 3 out of 9 horses following the initial glycopyrrolate treatment. Overall changes in HR and mean BP were not significantly different, while systolic and diastolic BP increased significantly (P < 0.025 using a Bonferroni corrected paired t- test). On the 2nd treatment, 3 out 7 horses given 2.5 μg/kg BW glycopyrrolate, and 4 out of 5 horses given 5.0 μg/kg BW (total dose) showed an increase in heart rate of > 5 beats/min, which was significant. A significant increase in BP was produced following treatment with 2.5 μg/kg BW, but not following 5.0 μg/kg BW. A final increase in HR, of > 5 beats/min, was associated with a significant rise in BP (P < 0.05 using an unpaired t-test). In conclusion, an increase in HR can occur with 2.5 to 5.0 μg of glycopyrrolate/kg BW, IV, and results in improvement in BP in anesthetized horses.

UR - http://www.scopus.com/inward/record.url?scp=0032953554&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032953554&partnerID=8YFLogxK

M3 - Article

VL - 40

SP - 29

EP - 32

JO - Canadian Veterinary Journal

JF - Canadian Veterinary Journal

SN - 0008-5286

IS - 1

ER -