Abstract
Objective-To determine effects of a continuous rate infusion of lidocaine on the minimum alveolar concentration (MAC) of sevofurane in horses. Animals-8 healthy adult horses. Procedures-Horses were anesthetized via IV administration of xylazine, ketamine, and di-azepam; anesthesia was maintained with sevofurane in oxygen. Approximately 1 hour after induction, sevofurane MAC determination was initiated via standard techniques. Following sevofurane MAC determination, lidocaine was administered as a bolus (1.3 mg/kg, IV, over 15 minutes), followed by constant rate infusion at 50 μg/kg/min. Determination of MAC for the lidocaine-sevofurane combination was started 30 minutes after lidocaine infusion was initiated. Arterial blood samples were collected after the lidocaine bolus, at 30-minute intervals, and at the end of the infusion for measurement of plasma lidocaine concentrations. Results-IV administration of lidocaine decreased mean ± SD sevofurane MAC from 2.42 ± 0.24% to 1.78 ± 0.38% (mean MAC reduction, 26.7 ± 12%). Plasma lidocaine concentrations were 2,589 ± 811 ng/mL at the end of the bolus; 2,065 ± 441 ng/mL, 2,243 ± 699 ng/ mL, 2,168 ± 339 ng/mL, and 2,254 ± 215 ng/mL at 30, 60, 90, and 120 minutes of infusion, respectively; and 2,206 ± 329 ng/mL at the end of the infusion. Plasma concentrations did not differ significantly among time points. Conclusions and Clinical Relevance-Lidocaine could be useful for providing a more balanced anesthetic technique in horses. A detailed cardiovascular study on the effects of IV infusion of lidocaine during anesthesia with sevofurane is required before this combination can be recommended.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 446-451 |
| Number of pages | 6 |
| Journal | American Journal of Veterinary Research |
| Volume | 72 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2011 |
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Effects of intravenous administration of lidocaine on the minimum alveolar concentration of sevofurane in horses. / Rezende, Marlis L.; Wagner, Ann E.; Mama, Khursheed R.; Ferreira, Tatiana H.; Steffey, Eugene.
In: American Journal of Veterinary Research, Vol. 72, No. 4, 01.04.2011, p. 446-451.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of intravenous administration of lidocaine on the minimum alveolar concentration of sevofurane in horses
AU - Rezende, Marlis L.
AU - Wagner, Ann E.
AU - Mama, Khursheed R.
AU - Ferreira, Tatiana H.
AU - Steffey, Eugene
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Objective-To determine effects of a continuous rate infusion of lidocaine on the minimum alveolar concentration (MAC) of sevofurane in horses. Animals-8 healthy adult horses. Procedures-Horses were anesthetized via IV administration of xylazine, ketamine, and di-azepam; anesthesia was maintained with sevofurane in oxygen. Approximately 1 hour after induction, sevofurane MAC determination was initiated via standard techniques. Following sevofurane MAC determination, lidocaine was administered as a bolus (1.3 mg/kg, IV, over 15 minutes), followed by constant rate infusion at 50 μg/kg/min. Determination of MAC for the lidocaine-sevofurane combination was started 30 minutes after lidocaine infusion was initiated. Arterial blood samples were collected after the lidocaine bolus, at 30-minute intervals, and at the end of the infusion for measurement of plasma lidocaine concentrations. Results-IV administration of lidocaine decreased mean ± SD sevofurane MAC from 2.42 ± 0.24% to 1.78 ± 0.38% (mean MAC reduction, 26.7 ± 12%). Plasma lidocaine concentrations were 2,589 ± 811 ng/mL at the end of the bolus; 2,065 ± 441 ng/mL, 2,243 ± 699 ng/ mL, 2,168 ± 339 ng/mL, and 2,254 ± 215 ng/mL at 30, 60, 90, and 120 minutes of infusion, respectively; and 2,206 ± 329 ng/mL at the end of the infusion. Plasma concentrations did not differ significantly among time points. Conclusions and Clinical Relevance-Lidocaine could be useful for providing a more balanced anesthetic technique in horses. A detailed cardiovascular study on the effects of IV infusion of lidocaine during anesthesia with sevofurane is required before this combination can be recommended.
AB - Objective-To determine effects of a continuous rate infusion of lidocaine on the minimum alveolar concentration (MAC) of sevofurane in horses. Animals-8 healthy adult horses. Procedures-Horses were anesthetized via IV administration of xylazine, ketamine, and di-azepam; anesthesia was maintained with sevofurane in oxygen. Approximately 1 hour after induction, sevofurane MAC determination was initiated via standard techniques. Following sevofurane MAC determination, lidocaine was administered as a bolus (1.3 mg/kg, IV, over 15 minutes), followed by constant rate infusion at 50 μg/kg/min. Determination of MAC for the lidocaine-sevofurane combination was started 30 minutes after lidocaine infusion was initiated. Arterial blood samples were collected after the lidocaine bolus, at 30-minute intervals, and at the end of the infusion for measurement of plasma lidocaine concentrations. Results-IV administration of lidocaine decreased mean ± SD sevofurane MAC from 2.42 ± 0.24% to 1.78 ± 0.38% (mean MAC reduction, 26.7 ± 12%). Plasma lidocaine concentrations were 2,589 ± 811 ng/mL at the end of the bolus; 2,065 ± 441 ng/mL, 2,243 ± 699 ng/ mL, 2,168 ± 339 ng/mL, and 2,254 ± 215 ng/mL at 30, 60, 90, and 120 minutes of infusion, respectively; and 2,206 ± 329 ng/mL at the end of the infusion. Plasma concentrations did not differ significantly among time points. Conclusions and Clinical Relevance-Lidocaine could be useful for providing a more balanced anesthetic technique in horses. A detailed cardiovascular study on the effects of IV infusion of lidocaine during anesthesia with sevofurane is required before this combination can be recommended.
UR - http://www.scopus.com/inward/record.url?scp=79955538836&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79955538836&partnerID=8YFLogxK
U2 - 10.2460/ajvr.72.4.446
DO - 10.2460/ajvr.72.4.446
M3 - Article
C2 - 21453144
AN - SCOPUS:79955538836
VL - 72
SP - 446
EP - 451
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 4
ER -