Effects of intravenous administration of lidocaine on the minimum alveolar concentration of sevofurane in horses

Marlis L. Rezende, Ann E. Wagner, Khursheed R. Mama, Tatiana H. Ferreira, Eugene Steffey

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Objective-To determine effects of a continuous rate infusion of lidocaine on the minimum alveolar concentration (MAC) of sevofurane in horses. Animals-8 healthy adult horses. Procedures-Horses were anesthetized via IV administration of xylazine, ketamine, and di-azepam; anesthesia was maintained with sevofurane in oxygen. Approximately 1 hour after induction, sevofurane MAC determination was initiated via standard techniques. Following sevofurane MAC determination, lidocaine was administered as a bolus (1.3 mg/kg, IV, over 15 minutes), followed by constant rate infusion at 50 μg/kg/min. Determination of MAC for the lidocaine-sevofurane combination was started 30 minutes after lidocaine infusion was initiated. Arterial blood samples were collected after the lidocaine bolus, at 30-minute intervals, and at the end of the infusion for measurement of plasma lidocaine concentrations. Results-IV administration of lidocaine decreased mean ± SD sevofurane MAC from 2.42 ± 0.24% to 1.78 ± 0.38% (mean MAC reduction, 26.7 ± 12%). Plasma lidocaine concentrations were 2,589 ± 811 ng/mL at the end of the bolus; 2,065 ± 441 ng/mL, 2,243 ± 699 ng/ mL, 2,168 ± 339 ng/mL, and 2,254 ± 215 ng/mL at 30, 60, 90, and 120 minutes of infusion, respectively; and 2,206 ± 329 ng/mL at the end of the infusion. Plasma concentrations did not differ significantly among time points. Conclusions and Clinical Relevance-Lidocaine could be useful for providing a more balanced anesthetic technique in horses. A detailed cardiovascular study on the effects of IV infusion of lidocaine during anesthesia with sevofurane is required before this combination can be recommended.

Original languageEnglish (US)
Pages (from-to)446-451
Number of pages6
JournalAmerican Journal of Veterinary Research
Volume72
Issue number4
DOIs
StatePublished - Apr 1 2011

Fingerprint

lidocaine
Lidocaine
intravenous injection
Intravenous Administration
Horses
horses
anesthesia
Anesthesia
Xylazine
xylazine
Ketamine
ketamine
anesthetics
Anesthetics
Oxygen
oxygen

ASJC Scopus subject areas

  • veterinary(all)

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Effects of intravenous administration of lidocaine on the minimum alveolar concentration of sevofurane in horses. / Rezende, Marlis L.; Wagner, Ann E.; Mama, Khursheed R.; Ferreira, Tatiana H.; Steffey, Eugene.

In: American Journal of Veterinary Research, Vol. 72, No. 4, 01.04.2011, p. 446-451.

Research output: Contribution to journalArticle

Rezende, Marlis L. ; Wagner, Ann E. ; Mama, Khursheed R. ; Ferreira, Tatiana H. ; Steffey, Eugene. / Effects of intravenous administration of lidocaine on the minimum alveolar concentration of sevofurane in horses. In: American Journal of Veterinary Research. 2011 ; Vol. 72, No. 4. pp. 446-451.
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abstract = "Objective-To determine effects of a continuous rate infusion of lidocaine on the minimum alveolar concentration (MAC) of sevofurane in horses. Animals-8 healthy adult horses. Procedures-Horses were anesthetized via IV administration of xylazine, ketamine, and di-azepam; anesthesia was maintained with sevofurane in oxygen. Approximately 1 hour after induction, sevofurane MAC determination was initiated via standard techniques. Following sevofurane MAC determination, lidocaine was administered as a bolus (1.3 mg/kg, IV, over 15 minutes), followed by constant rate infusion at 50 μg/kg/min. Determination of MAC for the lidocaine-sevofurane combination was started 30 minutes after lidocaine infusion was initiated. Arterial blood samples were collected after the lidocaine bolus, at 30-minute intervals, and at the end of the infusion for measurement of plasma lidocaine concentrations. Results-IV administration of lidocaine decreased mean ± SD sevofurane MAC from 2.42 ± 0.24{\%} to 1.78 ± 0.38{\%} (mean MAC reduction, 26.7 ± 12{\%}). Plasma lidocaine concentrations were 2,589 ± 811 ng/mL at the end of the bolus; 2,065 ± 441 ng/mL, 2,243 ± 699 ng/ mL, 2,168 ± 339 ng/mL, and 2,254 ± 215 ng/mL at 30, 60, 90, and 120 minutes of infusion, respectively; and 2,206 ± 329 ng/mL at the end of the infusion. Plasma concentrations did not differ significantly among time points. Conclusions and Clinical Relevance-Lidocaine could be useful for providing a more balanced anesthetic technique in horses. A detailed cardiovascular study on the effects of IV infusion of lidocaine during anesthesia with sevofurane is required before this combination can be recommended.",
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