Effects of inflammation on plasma composition and endothelial structure and function

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Changes in plasma protein composition normally associated with malnutrition, specifically hypoalbuminemia and reduced levels of tranferrin and prealbumin, usually only occur in the presence of preterminal starvation in the absence of inflammation. Thus, reduced levels of any of these proteins suggest that the inflammatory response has been activated. Inflammation also alters lipoprotein structure and function, and oxidation of low-density lipoprotein (LDL). This decreases high-density lipoprotein (HDL) levels and reduces its capacity to function as an antioxidant, and increases the levels of proteins, such as fibrinogen, associated with vascular disease. Cytokines and acute phase proteins, such as C-reactive protein (CRP), also up-regulate expression of adhesion molecules on the vascular endothelium, making them more effective targets for macrophage adhesion. Leukocyte-derived myeloperoxidase functions as an "NO oxidase" in the inflamed vasculature and contributes to decreased NO bioavailability and compromises vascular reactivity. The link between inflammation and apparent malnutrition explains the relationship between low levels of albumin, prealbumin, and transferrin with subsequent cardiovascular risk.

Original languageEnglish (US)
Pages (from-to)94-98
Number of pages5
JournalJournal of Renal Nutrition
Volume15
Issue number1
DOIs
StatePublished - Jan 2005

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Urology
  • Food Science
  • Clinical Neurology

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