Effects of indwelling nasogastric intubation on gastric emptying of a liquid marker in horses

Antonio M. Cruz, Ronald H L Li, Dan G. Kenney, Gabrielle Monteith

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective - To determine the effects of indwelling nasogastric intubation on the gastric emptying rate of liquid in horses. Animals - 6 healthy horses. Procedures - Horses were assigned to treatment and control groups in a prospective randomized crossover study with a washout period of at least 4 weeks between trials. Acetaminophen (20 mg/kg) diluted in 1 L of distilled water was administered via nasogastric tube at time points of 0, 12, 30, 48, and 72 hours to evaluate the liquid-phase gastric emptying rate. In control horses, nasogastric tubes were removed after administration of acetaminophen. In horses receiving treatment, the tube was left indwelling and maintained for 72 hours. A 10-mL sample of blood was collected from a jugular vein immediately before and 20, 40, 60, 80, 100, 120, and 180 minutes after acetaminophen administration. Serum acetaminophen concentrations were measured by use of a colorimetric method. Results - Peak serum acetaminophen concentration was significantly higher in the control group (38.11 μg/mL) than in the treatment group (29.09 μg/mL), and the time required to reach peak serum acetaminophen concentration was significantly shorter in the control group (22.79 minutes) than in the treatment group (35.95 minutes). Conclusions and Clinical Relevance - Results indicated that indwelling nasogastric intubation has a delaying effect on the gastric emptying rate of liquids. Veterinarians should consider the potential for delayed gastric emptying when placing and maintaining an indwelling nasogastric tube for an extended period of time after surgery. Repeated nasogastric intubation may be better than maintenance of an indwelling tube in horses with ileus.

Original languageEnglish (US)
Pages (from-to)1100-1104
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume67
Issue number7
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

Fingerprint

Gastrointestinal Intubation
acetaminophen
gastric emptying
Gastric Emptying
enteral feeding
Acetaminophen
Horses
horses
liquids
blood serum
Control Groups
Serum
Veterinarians
Ileus
intestinal obstruction
Jugular Veins
jugular vein
Therapeutics
Cross-Over Studies
veterinarians

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of indwelling nasogastric intubation on gastric emptying of a liquid marker in horses. / Cruz, Antonio M.; Li, Ronald H L; Kenney, Dan G.; Monteith, Gabrielle.

In: American Journal of Veterinary Research, Vol. 67, No. 7, 01.07.2006, p. 1100-1104.

Research output: Contribution to journalArticle

Cruz, Antonio M. ; Li, Ronald H L ; Kenney, Dan G. ; Monteith, Gabrielle. / Effects of indwelling nasogastric intubation on gastric emptying of a liquid marker in horses. In: American Journal of Veterinary Research. 2006 ; Vol. 67, No. 7. pp. 1100-1104.
@article{80febc495adf466f9bd8ca5344546857,
title = "Effects of indwelling nasogastric intubation on gastric emptying of a liquid marker in horses",
abstract = "Objective - To determine the effects of indwelling nasogastric intubation on the gastric emptying rate of liquid in horses. Animals - 6 healthy horses. Procedures - Horses were assigned to treatment and control groups in a prospective randomized crossover study with a washout period of at least 4 weeks between trials. Acetaminophen (20 mg/kg) diluted in 1 L of distilled water was administered via nasogastric tube at time points of 0, 12, 30, 48, and 72 hours to evaluate the liquid-phase gastric emptying rate. In control horses, nasogastric tubes were removed after administration of acetaminophen. In horses receiving treatment, the tube was left indwelling and maintained for 72 hours. A 10-mL sample of blood was collected from a jugular vein immediately before and 20, 40, 60, 80, 100, 120, and 180 minutes after acetaminophen administration. Serum acetaminophen concentrations were measured by use of a colorimetric method. Results - Peak serum acetaminophen concentration was significantly higher in the control group (38.11 μg/mL) than in the treatment group (29.09 μg/mL), and the time required to reach peak serum acetaminophen concentration was significantly shorter in the control group (22.79 minutes) than in the treatment group (35.95 minutes). Conclusions and Clinical Relevance - Results indicated that indwelling nasogastric intubation has a delaying effect on the gastric emptying rate of liquids. Veterinarians should consider the potential for delayed gastric emptying when placing and maintaining an indwelling nasogastric tube for an extended period of time after surgery. Repeated nasogastric intubation may be better than maintenance of an indwelling tube in horses with ileus.",
author = "Cruz, {Antonio M.} and Li, {Ronald H L} and Kenney, {Dan G.} and Gabrielle Monteith",
year = "2006",
month = "7",
day = "1",
doi = "10.2460/ajvr.67.7.1100",
language = "English (US)",
volume = "67",
pages = "1100--1104",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "7",

}

TY - JOUR

T1 - Effects of indwelling nasogastric intubation on gastric emptying of a liquid marker in horses

AU - Cruz, Antonio M.

AU - Li, Ronald H L

AU - Kenney, Dan G.

AU - Monteith, Gabrielle

PY - 2006/7/1

Y1 - 2006/7/1

N2 - Objective - To determine the effects of indwelling nasogastric intubation on the gastric emptying rate of liquid in horses. Animals - 6 healthy horses. Procedures - Horses were assigned to treatment and control groups in a prospective randomized crossover study with a washout period of at least 4 weeks between trials. Acetaminophen (20 mg/kg) diluted in 1 L of distilled water was administered via nasogastric tube at time points of 0, 12, 30, 48, and 72 hours to evaluate the liquid-phase gastric emptying rate. In control horses, nasogastric tubes were removed after administration of acetaminophen. In horses receiving treatment, the tube was left indwelling and maintained for 72 hours. A 10-mL sample of blood was collected from a jugular vein immediately before and 20, 40, 60, 80, 100, 120, and 180 minutes after acetaminophen administration. Serum acetaminophen concentrations were measured by use of a colorimetric method. Results - Peak serum acetaminophen concentration was significantly higher in the control group (38.11 μg/mL) than in the treatment group (29.09 μg/mL), and the time required to reach peak serum acetaminophen concentration was significantly shorter in the control group (22.79 minutes) than in the treatment group (35.95 minutes). Conclusions and Clinical Relevance - Results indicated that indwelling nasogastric intubation has a delaying effect on the gastric emptying rate of liquids. Veterinarians should consider the potential for delayed gastric emptying when placing and maintaining an indwelling nasogastric tube for an extended period of time after surgery. Repeated nasogastric intubation may be better than maintenance of an indwelling tube in horses with ileus.

AB - Objective - To determine the effects of indwelling nasogastric intubation on the gastric emptying rate of liquid in horses. Animals - 6 healthy horses. Procedures - Horses were assigned to treatment and control groups in a prospective randomized crossover study with a washout period of at least 4 weeks between trials. Acetaminophen (20 mg/kg) diluted in 1 L of distilled water was administered via nasogastric tube at time points of 0, 12, 30, 48, and 72 hours to evaluate the liquid-phase gastric emptying rate. In control horses, nasogastric tubes were removed after administration of acetaminophen. In horses receiving treatment, the tube was left indwelling and maintained for 72 hours. A 10-mL sample of blood was collected from a jugular vein immediately before and 20, 40, 60, 80, 100, 120, and 180 minutes after acetaminophen administration. Serum acetaminophen concentrations were measured by use of a colorimetric method. Results - Peak serum acetaminophen concentration was significantly higher in the control group (38.11 μg/mL) than in the treatment group (29.09 μg/mL), and the time required to reach peak serum acetaminophen concentration was significantly shorter in the control group (22.79 minutes) than in the treatment group (35.95 minutes). Conclusions and Clinical Relevance - Results indicated that indwelling nasogastric intubation has a delaying effect on the gastric emptying rate of liquids. Veterinarians should consider the potential for delayed gastric emptying when placing and maintaining an indwelling nasogastric tube for an extended period of time after surgery. Repeated nasogastric intubation may be better than maintenance of an indwelling tube in horses with ileus.

UR - http://www.scopus.com/inward/record.url?scp=33747617833&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33747617833&partnerID=8YFLogxK

U2 - 10.2460/ajvr.67.7.1100

DO - 10.2460/ajvr.67.7.1100

M3 - Article

C2 - 16817727

AN - SCOPUS:33747617833

VL - 67

SP - 1100

EP - 1104

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 7

ER -