Effects of in vivo perforant path kindling on 0-Mg2+-induced CA1 burst activity in rat hippocampal slices

Scott E. Krahl, Loraine M. Treas, Robert F Berman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previous studies have reported persistent alterations in the electrophysiological characteristics of the CA1 region of the hippocampus after kindling. The present study examined the effects of perforant path kindling on 0-Mg2+-induced epileptiform bursting in the CA1 region of hippocampal slices. The duration of evoked bursting was significantly longer in slices taken from kindled animals as compared to those taken from implanted, non-stimulated controls. No significant differences were found in spontaneous burst frequency between slices taken from kindled and control animals. These data suggest that perforant path kindling causes a persistent increase in hyperexcitability in the CA1 region of the hippocampus leading to a facilitation of evoked burst activity, perhaps through an enhancement in NMDA-related excitatory neurotransmission.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
JournalBrain Research
Volume723
Issue number1-2
DOIs
StatePublished - Jun 3 1996
Externally publishedYes

Fingerprint

Perforant Pathway
Hippocampus
Hippocampal CA1 Region
N-Methylaspartate
Synaptic Transmission

Keywords

  • CA1
  • Epilepsy
  • Hippocampus
  • Kindling
  • Perforant path

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Effects of in vivo perforant path kindling on 0-Mg2+-induced CA1 burst activity in rat hippocampal slices. / Krahl, Scott E.; Treas, Loraine M.; Berman, Robert F.

In: Brain Research, Vol. 723, No. 1-2, 03.06.1996, p. 196-198.

Research output: Contribution to journalArticle

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