Effects of hyposmolar solutions on membrane currents of hippocampal interneurons and mossy cells in vitro

Scott C. Baraban, Philip A Schwartzkroin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Whole cell voltage-clamp recordings in rat hippocampal slices were used to investigate the effect of changes in extracellular osmolarity on voltage- activated potassium currents. Currents were evoked from oriens/alveus (O/A) interneurons, hilar interneurons, and mossy cells. Hyposmolar external solutions produced a significant potentiation of K+ current recorded from O/A and hilar interneurons, but not from mossy cells. Hyposmolar solutions also dramatically potentiated the spontaneous excitatory postsynaptic currents recorded from mossy cells. These results suggest that hippocampal excitability can be modulated by the complex actions exerted by changes in extracellular osmolarity.

Original languageEnglish (US)
Pages (from-to)1108-1112
Number of pages5
JournalJournal of Neurophysiology
Volume79
Issue number2
StatePublished - Feb 1998
Externally publishedYes

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Interneurons
Membranes
Osmolar Concentration
Excitatory Postsynaptic Potentials
Potassium
In Vitro Techniques

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Effects of hyposmolar solutions on membrane currents of hippocampal interneurons and mossy cells in vitro. / Baraban, Scott C.; Schwartzkroin, Philip A.

In: Journal of Neurophysiology, Vol. 79, No. 2, 02.1998, p. 1108-1112.

Research output: Contribution to journalArticle

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