Effects of Human Recombinant Granulocyte Colony Stimulating Factor (HR‐GCSF) on the Hemogram of Lactating Dairy Cattle

James S Cullor; W. Smith; N. Fairley; S. L. Wood; J. D. Dellinger; L. Souza

doi:10.1111/j.1939-165X.1990.tb00534.x

Effects of Human Recombinant Granulocyte Colony Stimulating Factor (HR‐GCSF) on the Hemogram of Lactating Dairy Cattle

James S Cullor, W. Smith, N. Fairley, S. L. Wood, J. D. Dellinger, L. Souza

Population Health and Reproduction

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Mastitis commonly occurs in the dairy cow and results in an influx of granulocytes into the mammary gland. Presently, colony stimulating factors have been isolated. One factor, granulocyte colony stimulating factor (GCSF), has been identified and reproduced using recombinant DNA technologies. In an experiment, lactating bovine were given a bacterially‐synthesized human recombinant granulocytic colony stimulating factor (Hr‐GCSF) at a specified dose rate to monitor and characterize their hematological responses. Doses of Hr‐GCSF were administered subcutaneously and blood samples collected from the tail vein into vacutainer tubes. Results of the study indicated a toleration by the bovine for the Hr‐GCSF for the tested period, and that the Hr‐GCSF can stimulate a sustained elevation of circulating neutrophils.

Original language	English (US)
Pages (from-to)	9-12
Number of pages	4
Journal	Veterinary Clinical Pathology
Volume	19
Issue number	1
DOIs	https://doi.org/10.1111/j.1939-165X.1990.tb00534.x
State	Published - 1990

Keywords

bovine
granulocyte colony stimulating factor (GCSF)
hematology
neutrophils

ASJC Scopus subject areas

veterinary(all)

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10.1111/j.1939-165X.1990.tb00534.x

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title = "Effects of Human Recombinant Granulocyte Colony Stimulating Factor (HR‐GCSF) on the Hemogram of Lactating Dairy Cattle",

abstract = "Mastitis commonly occurs in the dairy cow and results in an influx of granulocytes into the mammary gland. Presently, colony stimulating factors have been isolated. One factor, granulocyte colony stimulating factor (GCSF), has been identified and reproduced using recombinant DNA technologies. In an experiment, lactating bovine were given a bacterially‐synthesized human recombinant granulocytic colony stimulating factor (Hr‐GCSF) at a specified dose rate to monitor and characterize their hematological responses. Doses of Hr‐GCSF were administered subcutaneously and blood samples collected from the tail vein into vacutainer tubes. Results of the study indicated a toleration by the bovine for the Hr‐GCSF for the tested period, and that the Hr‐GCSF can stimulate a sustained elevation of circulating neutrophils.",

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author = "Cullor, {James S} and W. Smith and N. Fairley and Wood, {S. L.} and Dellinger, {J. D.} and L. Souza",

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AU - Wood, S. L.

AU - Dellinger, J. D.

AU - Souza, L.

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