Effects of Human Recombinant Granulocyte Colony Stimulating Factor (HR‐GCSF) on the Hemogram of Lactating Dairy Cattle

James S Cullor, W. Smith, N. Fairley, S. L. Wood, J. D. Dellinger, L. Souza

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Mastitis commonly occurs in the dairy cow and results in an influx of granulocytes into the mammary gland. Presently, colony stimulating factors have been isolated. One factor, granulocyte colony stimulating factor (GCSF), has been identified and reproduced using recombinant DNA technologies. In an experiment, lactating bovine were given a bacterially‐synthesized human recombinant granulocytic colony stimulating factor (Hr‐GCSF) at a specified dose rate to monitor and characterize their hematological responses. Doses of Hr‐GCSF were administered subcutaneously and blood samples collected from the tail vein into vacutainer tubes. Results of the study indicated a toleration by the bovine for the Hr‐GCSF for the tested period, and that the Hr‐GCSF can stimulate a sustained elevation of circulating neutrophils.

Original languageEnglish (US)
Pages (from-to)9-12
Number of pages4
JournalVeterinary Clinical Pathology
Volume19
Issue number1
DOIs
StatePublished - 1990

Keywords

  • bovine
  • granulocyte colony stimulating factor (GCSF)
  • hematology
  • neutrophils

ASJC Scopus subject areas

  • veterinary(all)

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