Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration

Kenneth Dorshkind, Lisbeth Welniak, Ruth A. Gault, Julie Hixon, Encarnacion Montecino-Rodriguez, Nelson D. Horseman, Joseph M. Gertner, William J Murphy

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Initial studies on T cell development in the Snell Dwarf (dw/dw) strain of mice, which are deficient in the production of anterior pituitary hormones, have been interpreted to indicate a clear dependence of T cell development on endocrine system-derived factors. However, normal thymopoiesis in this strain has also been reported. The aim of the present study was to reconcile these contradictory data in order to define the role of anterior pituitary hormones in the thymus. The results indicated that if female dw/dw mice are housed together with their normal-sized littermates, thymic cellularity and the frequency of CD4+CD8+ thymocytes are markedly reduced. However, administration of growth hormone could reverse these decreases seen in the double-positive T progenitor cells. Taken together, the data indicate that stress is the unifying parameter that can explain the disparate dw/dw mouse literature and suggest that endocrine effects on the T cell development can best be understood by interpreting the literature in this context.

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalClinical Immunology
Volume109
Issue number2
DOIs
StatePublished - Nov 2003
Externally publishedYes

Fingerprint

Anterior Pituitary Hormones
Growth Hormone
T-Lymphocytes
Endocrine System
Thymocytes
Thymus Gland
Stem Cells

Keywords

  • Growth hormone
  • Stress
  • T cell progenitor
  • Thymopoiesis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration. / Dorshkind, Kenneth; Welniak, Lisbeth; Gault, Ruth A.; Hixon, Julie; Montecino-Rodriguez, Encarnacion; Horseman, Nelson D.; Gertner, Joseph M.; Murphy, William J.

In: Clinical Immunology, Vol. 109, No. 2, 11.2003, p. 197-202.

Research output: Contribution to journalArticle

Dorshkind, K, Welniak, L, Gault, RA, Hixon, J, Montecino-Rodriguez, E, Horseman, ND, Gertner, JM & Murphy, WJ 2003, 'Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration', Clinical Immunology, vol. 109, no. 2, pp. 197-202. https://doi.org/10.1016/S1521-6616(03)00181-5
Dorshkind K, Welniak L, Gault RA, Hixon J, Montecino-Rodriguez E, Horseman ND et al. Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration. Clinical Immunology. 2003 Nov;109(2):197-202. https://doi.org/10.1016/S1521-6616(03)00181-5
Dorshkind, Kenneth ; Welniak, Lisbeth ; Gault, Ruth A. ; Hixon, Julie ; Montecino-Rodriguez, Encarnacion ; Horseman, Nelson D. ; Gertner, Joseph M. ; Murphy, William J. / Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration. In: Clinical Immunology. 2003 ; Vol. 109, No. 2. pp. 197-202.
@article{5568fe45ee5e46ba8796fa3121422084,
title = "Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration",
abstract = "Initial studies on T cell development in the Snell Dwarf (dw/dw) strain of mice, which are deficient in the production of anterior pituitary hormones, have been interpreted to indicate a clear dependence of T cell development on endocrine system-derived factors. However, normal thymopoiesis in this strain has also been reported. The aim of the present study was to reconcile these contradictory data in order to define the role of anterior pituitary hormones in the thymus. The results indicated that if female dw/dw mice are housed together with their normal-sized littermates, thymic cellularity and the frequency of CD4+CD8+ thymocytes are markedly reduced. However, administration of growth hormone could reverse these decreases seen in the double-positive T progenitor cells. Taken together, the data indicate that stress is the unifying parameter that can explain the disparate dw/dw mouse literature and suggest that endocrine effects on the T cell development can best be understood by interpreting the literature in this context.",
keywords = "Growth hormone, Stress, T cell progenitor, Thymopoiesis",
author = "Kenneth Dorshkind and Lisbeth Welniak and Gault, {Ruth A.} and Julie Hixon and Encarnacion Montecino-Rodriguez and Horseman, {Nelson D.} and Gertner, {Joseph M.} and Murphy, {William J}",
year = "2003",
month = "11",
doi = "10.1016/S1521-6616(03)00181-5",
language = "English (US)",
volume = "109",
pages = "197--202",
journal = "Clinical Immunology",
issn = "1521-6616",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Effects of housing on the thymic deficiency in dwarf mice and its reversal by growth hormone administration

AU - Dorshkind, Kenneth

AU - Welniak, Lisbeth

AU - Gault, Ruth A.

AU - Hixon, Julie

AU - Montecino-Rodriguez, Encarnacion

AU - Horseman, Nelson D.

AU - Gertner, Joseph M.

AU - Murphy, William J

PY - 2003/11

Y1 - 2003/11

N2 - Initial studies on T cell development in the Snell Dwarf (dw/dw) strain of mice, which are deficient in the production of anterior pituitary hormones, have been interpreted to indicate a clear dependence of T cell development on endocrine system-derived factors. However, normal thymopoiesis in this strain has also been reported. The aim of the present study was to reconcile these contradictory data in order to define the role of anterior pituitary hormones in the thymus. The results indicated that if female dw/dw mice are housed together with their normal-sized littermates, thymic cellularity and the frequency of CD4+CD8+ thymocytes are markedly reduced. However, administration of growth hormone could reverse these decreases seen in the double-positive T progenitor cells. Taken together, the data indicate that stress is the unifying parameter that can explain the disparate dw/dw mouse literature and suggest that endocrine effects on the T cell development can best be understood by interpreting the literature in this context.

AB - Initial studies on T cell development in the Snell Dwarf (dw/dw) strain of mice, which are deficient in the production of anterior pituitary hormones, have been interpreted to indicate a clear dependence of T cell development on endocrine system-derived factors. However, normal thymopoiesis in this strain has also been reported. The aim of the present study was to reconcile these contradictory data in order to define the role of anterior pituitary hormones in the thymus. The results indicated that if female dw/dw mice are housed together with their normal-sized littermates, thymic cellularity and the frequency of CD4+CD8+ thymocytes are markedly reduced. However, administration of growth hormone could reverse these decreases seen in the double-positive T progenitor cells. Taken together, the data indicate that stress is the unifying parameter that can explain the disparate dw/dw mouse literature and suggest that endocrine effects on the T cell development can best be understood by interpreting the literature in this context.

KW - Growth hormone

KW - Stress

KW - T cell progenitor

KW - Thymopoiesis

UR - http://www.scopus.com/inward/record.url?scp=0242302403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242302403&partnerID=8YFLogxK

U2 - 10.1016/S1521-6616(03)00181-5

DO - 10.1016/S1521-6616(03)00181-5

M3 - Article

C2 - 14597218

AN - SCOPUS:0242302403

VL - 109

SP - 197

EP - 202

JO - Clinical Immunology

JF - Clinical Immunology

SN - 1521-6616

IS - 2

ER -