Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice

Weicang Wang; Jun Yang; Haixia Yang; Katherine Z. Sanidad; Bruce D. Hammock; Daeyoung Kim; Guodong Zhang

doi:10.1016/j.prostaglandins.2016.11.003

Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice

Weicang Wang, Jun Yang, Haixia Yang, Katherine Z. Sanidad, Bruce D. Hammock, Daeyoung Kim, Guodong Zhang

Entomology

Research output: Contribution to journal › Article

8 Scopus citations

Abstract

Obesity is a serious health problem in the US and is associated with increased risks of various human diseases. To date, the mechanisms by which obesity increases the risks of a wide range of human diseases are not well understood. Here we used a LC–MS/MS-based lipidomics, which can analyze >100 bioactive lipid mediators produced by cyclooxygenase, lipoxygenase, and cytochrome P450 enzymes, to analyze plasma profiles of lipid mediators in high-fat diet induced obesity in C57BL/6 mice. Our results show that the plasma concentrations of epoxyoctadecenoic acids (EpOMEs, also termed as leukotoxins) are significantly increased in plasma of high-fat diet-fed mice, in addition, EpOMEs are among the most abundant lipid mediators detected in mouse plasma. Since substantial studies have shown that EpOMEs and their metabolites have a large array of detrimental effects on health, enhanced levels of EpOMEs could contribute to the pathology of obesity.

Original language	English (US)
Pages (from-to)	9-13
Number of pages	5
Journal	Prostaglandins and Other Lipid Mediators
Volume	127
DOIs	https://doi.org/10.1016/j.prostaglandins.2016.11.003
State	Published - Dec 1 2016

Keywords

Eicosanoids
Epoxyoctadecenoic acids
High-fat diet
Leukotoxins
Obesity

ASJC Scopus subject areas

Physiology
Biochemistry
Pharmacology
Cell Biology

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Wang, W., Yang, J., Yang, H., Sanidad, K. Z., Hammock, B. D., Kim, D., & Zhang, G. (2016). Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice. Prostaglandins and Other Lipid Mediators, 127, 9-13. https://doi.org/10.1016/j.prostaglandins.2016.11.003

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abstract = "Obesity is a serious health problem in the US and is associated with increased risks of various human diseases. To date, the mechanisms by which obesity increases the risks of a wide range of human diseases are not well understood. Here we used a LC–MS/MS-based lipidomics, which can analyze >100 bioactive lipid mediators produced by cyclooxygenase, lipoxygenase, and cytochrome P450 enzymes, to analyze plasma profiles of lipid mediators in high-fat diet induced obesity in C57BL/6 mice. Our results show that the plasma concentrations of epoxyoctadecenoic acids (EpOMEs, also termed as leukotoxins) are significantly increased in plasma of high-fat diet-fed mice, in addition, EpOMEs are among the most abundant lipid mediators detected in mouse plasma. Since substantial studies have shown that EpOMEs and their metabolites have a large array of detrimental effects on health, enhanced levels of EpOMEs could contribute to the pathology of obesity.",

keywords = "Eicosanoids, Epoxyoctadecenoic acids, High-fat diet, Leukotoxins, Obesity",

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AU - Yang, Haixia

AU - Sanidad, Katherine Z.

AU - Hammock, Bruce D.

AU - Kim, Daeyoung

AU - Zhang, Guodong

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