Effects of high-fat diet on plasma profiles of eicosanoid metabolites in mice

Weicang Wang, Jun Yang, Haixia Yang, Katherine Z. Sanidad, Bruce D. Hammock, Daeyoung Kim, Guodong Zhang

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Obesity is a serious health problem in the US and is associated with increased risks of various human diseases. To date, the mechanisms by which obesity increases the risks of a wide range of human diseases are not well understood. Here we used a LC–MS/MS-based lipidomics, which can analyze >100 bioactive lipid mediators produced by cyclooxygenase, lipoxygenase, and cytochrome P450 enzymes, to analyze plasma profiles of lipid mediators in high-fat diet induced obesity in C57BL/6 mice. Our results show that the plasma concentrations of epoxyoctadecenoic acids (EpOMEs, also termed as leukotoxins) are significantly increased in plasma of high-fat diet-fed mice, in addition, EpOMEs are among the most abundant lipid mediators detected in mouse plasma. Since substantial studies have shown that EpOMEs and their metabolites have a large array of detrimental effects on health, enhanced levels of EpOMEs could contribute to the pathology of obesity.

Original languageEnglish (US)
Pages (from-to)9-13
Number of pages5
JournalProstaglandins and Other Lipid Mediators
Volume127
DOIs
StatePublished - Dec 1 2016

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Keywords

  • Eicosanoids
  • Epoxyoctadecenoic acids
  • High-fat diet
  • Leukotoxins
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Pharmacology
  • Cell Biology

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