TY - JOUR
T1 - Effects of high dietary methionine on activities of selected enzymes in the liver of kittens (felis domesticus)
AU - Fau, Daniel
AU - Morris, James
AU - Rogers, Quinton
PY - 1987/1/1
Y1 - 1987/1/1
N2 - 1. 1. Growing male kittens were fed an 18% casein diet supplemented with 2, 3, or 4% l-methionine (MET) for 6 weeks. 2. 2. Free MET concentration in liver increased 30-fold and cystathionine two- to three-fold; the activity of adenosyl-MET transferase and cystathionase also increased but remained lower than previously found in rats. 3. 3. Taurine concentration in liver decreased in cats fed excess MET and appeared to depend on taurine intake. 4. 4. Alanine aminotransferase activity was high in all groups while serine dehydratase activity was very low. 5. 5. Pyruvate kinase and malic enzyme activities which are normally low in cat liver increased after excess MET. Also, glucose 6-phosphate and 6-phosphogluconate dehydrogenases increased. 6. 6. Cat liver metabolism showed limited adaptation to an excess dietary intake of methionine compared to that found in rats.
AB - 1. 1. Growing male kittens were fed an 18% casein diet supplemented with 2, 3, or 4% l-methionine (MET) for 6 weeks. 2. 2. Free MET concentration in liver increased 30-fold and cystathionine two- to three-fold; the activity of adenosyl-MET transferase and cystathionase also increased but remained lower than previously found in rats. 3. 3. Taurine concentration in liver decreased in cats fed excess MET and appeared to depend on taurine intake. 4. 4. Alanine aminotransferase activity was high in all groups while serine dehydratase activity was very low. 5. 5. Pyruvate kinase and malic enzyme activities which are normally low in cat liver increased after excess MET. Also, glucose 6-phosphate and 6-phosphogluconate dehydrogenases increased. 6. 6. Cat liver metabolism showed limited adaptation to an excess dietary intake of methionine compared to that found in rats.
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U2 - 10.1016/0305-0491(87)90343-9
DO - 10.1016/0305-0491(87)90343-9
M3 - Article
C2 - 3427903
AN - SCOPUS:0023480548
VL - 88
SP - 551
EP - 555
JO - Comparative biochemistry and physiology. B, Comparative biochemistry
JF - Comparative biochemistry and physiology. B, Comparative biochemistry
SN - 1096-4959
IS - 2
ER -