Effects of haloperidol on recall and information processing in verbal and spatial learning

Dan M Mungas, Joseph R. Magliozzi, Justine N. Laubly, Dale Blunden

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

1. Normal male subjects were tested with either a multi-trial word list learning test or a spatial analogue prior to administration of either 4 mg. or 10 mg. of oral haloperidol. Six hours after drug administration subjects who had previously received the verbal test were administered the spatial test, and vice versa, so for each test there was a no-drug control group, a group tested after receiving 4 mg. of haloperidol, and a group tested after a 10 mg. dose. 2. Both the verbal and spatial learning tests yield multidimensional measures of components of memory and learning, including measures sensitive to effort-demanding and more automatic information processing operations. 3. Results showed no differences for either test among the pre-drug control group and the 4 mg. and 10 mg. groups, with only one minor exception. 4. The lack of significant results cannot be attributed to insensitivity of the test instruments used, since previous studies have documented sensitivity to a number of clinical conditions and to aging. 5. Results have implications regarding clinical effects of haloperidol. A theory that links dopaminergic functioning with effortful information processing underlying memory and learning was not supported.

Original languageEnglish (US)
Pages (from-to)181-193
Number of pages13
JournalProgress in Neuropsychopharmacology and Biological Psychiatry
Volume14
Issue number2
DOIs
StatePublished - 1990

Fingerprint

Verbal Learning
Haloperidol
Automatic Data Processing
Drug and Narcotic Control
Learning
Control Groups
Pharmaceutical Preparations
Spatial Learning

Keywords

  • cognitive functions
  • haloperidol
  • spatial memory
  • verbal memory

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology

Cite this

Effects of haloperidol on recall and information processing in verbal and spatial learning. / Mungas, Dan M; Magliozzi, Joseph R.; Laubly, Justine N.; Blunden, Dale.

In: Progress in Neuropsychopharmacology and Biological Psychiatry, Vol. 14, No. 2, 1990, p. 181-193.

Research output: Contribution to journalArticle

@article{ef558808bb4343f68dc7e81e32e30752,
title = "Effects of haloperidol on recall and information processing in verbal and spatial learning",
abstract = "1. Normal male subjects were tested with either a multi-trial word list learning test or a spatial analogue prior to administration of either 4 mg. or 10 mg. of oral haloperidol. Six hours after drug administration subjects who had previously received the verbal test were administered the spatial test, and vice versa, so for each test there was a no-drug control group, a group tested after receiving 4 mg. of haloperidol, and a group tested after a 10 mg. dose. 2. Both the verbal and spatial learning tests yield multidimensional measures of components of memory and learning, including measures sensitive to effort-demanding and more automatic information processing operations. 3. Results showed no differences for either test among the pre-drug control group and the 4 mg. and 10 mg. groups, with only one minor exception. 4. The lack of significant results cannot be attributed to insensitivity of the test instruments used, since previous studies have documented sensitivity to a number of clinical conditions and to aging. 5. Results have implications regarding clinical effects of haloperidol. A theory that links dopaminergic functioning with effortful information processing underlying memory and learning was not supported.",
keywords = "cognitive functions, haloperidol, spatial memory, verbal memory",
author = "Mungas, {Dan M} and Magliozzi, {Joseph R.} and Laubly, {Justine N.} and Dale Blunden",
year = "1990",
doi = "10.1016/0278-5846(90)90100-U",
language = "English (US)",
volume = "14",
pages = "181--193",
journal = "Progress in Neuro-Psychopharmacology and Biological Psychiatry",
issn = "0278-5846",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Effects of haloperidol on recall and information processing in verbal and spatial learning

AU - Mungas, Dan M

AU - Magliozzi, Joseph R.

AU - Laubly, Justine N.

AU - Blunden, Dale

PY - 1990

Y1 - 1990

N2 - 1. Normal male subjects were tested with either a multi-trial word list learning test or a spatial analogue prior to administration of either 4 mg. or 10 mg. of oral haloperidol. Six hours after drug administration subjects who had previously received the verbal test were administered the spatial test, and vice versa, so for each test there was a no-drug control group, a group tested after receiving 4 mg. of haloperidol, and a group tested after a 10 mg. dose. 2. Both the verbal and spatial learning tests yield multidimensional measures of components of memory and learning, including measures sensitive to effort-demanding and more automatic information processing operations. 3. Results showed no differences for either test among the pre-drug control group and the 4 mg. and 10 mg. groups, with only one minor exception. 4. The lack of significant results cannot be attributed to insensitivity of the test instruments used, since previous studies have documented sensitivity to a number of clinical conditions and to aging. 5. Results have implications regarding clinical effects of haloperidol. A theory that links dopaminergic functioning with effortful information processing underlying memory and learning was not supported.

AB - 1. Normal male subjects were tested with either a multi-trial word list learning test or a spatial analogue prior to administration of either 4 mg. or 10 mg. of oral haloperidol. Six hours after drug administration subjects who had previously received the verbal test were administered the spatial test, and vice versa, so for each test there was a no-drug control group, a group tested after receiving 4 mg. of haloperidol, and a group tested after a 10 mg. dose. 2. Both the verbal and spatial learning tests yield multidimensional measures of components of memory and learning, including measures sensitive to effort-demanding and more automatic information processing operations. 3. Results showed no differences for either test among the pre-drug control group and the 4 mg. and 10 mg. groups, with only one minor exception. 4. The lack of significant results cannot be attributed to insensitivity of the test instruments used, since previous studies have documented sensitivity to a number of clinical conditions and to aging. 5. Results have implications regarding clinical effects of haloperidol. A theory that links dopaminergic functioning with effortful information processing underlying memory and learning was not supported.

KW - cognitive functions

KW - haloperidol

KW - spatial memory

KW - verbal memory

UR - http://www.scopus.com/inward/record.url?scp=0025090018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025090018&partnerID=8YFLogxK

U2 - 10.1016/0278-5846(90)90100-U

DO - 10.1016/0278-5846(90)90100-U

M3 - Article

C2 - 2309036

AN - SCOPUS:0025090018

VL - 14

SP - 181

EP - 193

JO - Progress in Neuro-Psychopharmacology and Biological Psychiatry

JF - Progress in Neuro-Psychopharmacology and Biological Psychiatry

SN - 0278-5846

IS - 2

ER -