Effects of growth hormone and prolactin on hematopoiesis

Lisbeth A. Welniak, Zhi Gang Tian, Rui Sun, Jonathan R. Keller, Susan Richards, Francis W. Ruscetti, William J Murphy

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The use of the neuroendocrine hormones growth hormone (GH) and prolactin (PRL) in preclinical models, demonstrating promotion of hematopoietic recovery and immune function, offers promise for several clinical situations. These hormones do not appear to produce the same extent of immune/hematopoietic effects when compared to conventional hematopoietic and immune stimulating cytokines (i.e. G-CSF or interleukin-2). However, their pleiotropic effects and limited toxicity after systemic administration makes them attractive to test in myeloablative situations. More work needs to be performed to understand the mechanism(s) of GH and PRL action, particularly with regard to hematopoietic progenitor cell expansion and differentiation both in normal and pathologic situations.

Original languageEnglish (US)
Pages (from-to)435-445
Number of pages11
JournalLeukemia and Lymphoma
Volume38
Issue number5-6
StatePublished - 2000
Externally publishedYes

Fingerprint

Hematopoiesis
Prolactin
Growth Hormone
Hormones
Recovery of Function
Granulocyte Colony-Stimulating Factor
Hematopoietic Stem Cells
Interleukin-2
Cell Differentiation
Cytokines

Keywords

  • Growth hormone
  • Hematopoiesis
  • IGF-I
  • Myelosuppression
  • Prolactin
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Welniak, L. A., Tian, Z. G., Sun, R., Keller, J. R., Richards, S., Ruscetti, F. W., & Murphy, W. J. (2000). Effects of growth hormone and prolactin on hematopoiesis. Leukemia and Lymphoma, 38(5-6), 435-445.

Effects of growth hormone and prolactin on hematopoiesis. / Welniak, Lisbeth A.; Tian, Zhi Gang; Sun, Rui; Keller, Jonathan R.; Richards, Susan; Ruscetti, Francis W.; Murphy, William J.

In: Leukemia and Lymphoma, Vol. 38, No. 5-6, 2000, p. 435-445.

Research output: Contribution to journalArticle

Welniak, LA, Tian, ZG, Sun, R, Keller, JR, Richards, S, Ruscetti, FW & Murphy, WJ 2000, 'Effects of growth hormone and prolactin on hematopoiesis', Leukemia and Lymphoma, vol. 38, no. 5-6, pp. 435-445.
Welniak LA, Tian ZG, Sun R, Keller JR, Richards S, Ruscetti FW et al. Effects of growth hormone and prolactin on hematopoiesis. Leukemia and Lymphoma. 2000;38(5-6):435-445.
Welniak, Lisbeth A. ; Tian, Zhi Gang ; Sun, Rui ; Keller, Jonathan R. ; Richards, Susan ; Ruscetti, Francis W. ; Murphy, William J. / Effects of growth hormone and prolactin on hematopoiesis. In: Leukemia and Lymphoma. 2000 ; Vol. 38, No. 5-6. pp. 435-445.
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