Effects of fondaparinux on wound drainage after total hip and knee arthroplasty

Zachary C. Lum, Rene A. Monzon, Jose Bosque, Sheldon Coleman, Gavin Caesar Pereira, Paul E. Di Cesare

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: The purpose of this investigation was to determine the effects of fondaparinux on postoperative wound drainage, length of hospital stay (LOS) and rate of surgical site infection in total joint patients. Methods: 117 patients undergoing total joint arthroplasty treated with fondaparinux for venous thromboembolism (VTE) prophylaxis were prospectively studied. Results: The average time to a dry wound was 3.4 days, with an average LOS of 3.77 days. Perioperative complications included 2 cases each of superficial cellulitis, deep vein thrombosis, and pulmonary embolism; there were no cases of deep infection. Multi-variate analysis showed increased patient BMI increased LOS (p = 0.0169). Conclusion: Fondaparinux is an effective drug for VTE prophylaxis in total joint arthroplasty with wound drainage and LOS comparable to historical controls of enoxaparin, warfarin, and rivaroxaban.

Original languageEnglish (US)
Pages (from-to)388-390
Number of pages3
JournalJournal of Orthopaedics
Issue number2
StatePublished - Jun 1 2018


  • Anticoagulation in arthroplasty
  • Arixtra
  • Fondaparinux
  • Length of stay
  • Surgical site infections
  • Wound drainage in total joint arthroplasty

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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