Abstract
Circulatory and respiratory effects of five h of constant 1.06 per cent alveolar halothane in oxygen were identified in eight healthy horses, which breathed spontaneously, were otherwise unmedicated and positioned in sternal recumbency. Only a few important significant (P<0.05) changes occurred with time. Total peripheral resistance was about 15 per cent lower after two hours of constant dose halothane than after 30 mins of constant dose (P<0.05) and accounted for the significant 10 per cent reduction in mean carotid arterial blood pressure. By 5 h, the reduction in resistance and arterial blood pressure was 20 and 25 per cent respectively. Heart rate increased progressively with time and the increase became significant at 5 h (15 per cent increase). However, the heart rate change was not large enough to alter cardiac output. There were no major time‐related changes in PaO2 or PaCO2. Three of four horses recovered from anaesthesia had markedly elevated serum creatine kinase levels and clinical signs of severe post anaesthetic myopathy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 433-436 |
| Number of pages | 4 |
| Journal | Equine Veterinary Journal |
| Volume | 22 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1990 |
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ASJC Scopus subject areas
- Equine
Cite this
Effects of five hours of constant 1.2 MAC halothane in sternally recumbent, spontaneously breathing horses. / Steffey, Eugene; WOLINER, M. J.; DUNLOP, C.
In: Equine Veterinary Journal, Vol. 22, No. 6, 01.01.1990, p. 433-436.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of five hours of constant 1.2 MAC halothane in sternally recumbent, spontaneously breathing horses
AU - Steffey, Eugene
AU - WOLINER, M. J.
AU - DUNLOP, C.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - Circulatory and respiratory effects of five h of constant 1.06 per cent alveolar halothane in oxygen were identified in eight healthy horses, which breathed spontaneously, were otherwise unmedicated and positioned in sternal recumbency. Only a few important significant (P<0.05) changes occurred with time. Total peripheral resistance was about 15 per cent lower after two hours of constant dose halothane than after 30 mins of constant dose (P<0.05) and accounted for the significant 10 per cent reduction in mean carotid arterial blood pressure. By 5 h, the reduction in resistance and arterial blood pressure was 20 and 25 per cent respectively. Heart rate increased progressively with time and the increase became significant at 5 h (15 per cent increase). However, the heart rate change was not large enough to alter cardiac output. There were no major time‐related changes in PaO2 or PaCO2. Three of four horses recovered from anaesthesia had markedly elevated serum creatine kinase levels and clinical signs of severe post anaesthetic myopathy.
AB - Circulatory and respiratory effects of five h of constant 1.06 per cent alveolar halothane in oxygen were identified in eight healthy horses, which breathed spontaneously, were otherwise unmedicated and positioned in sternal recumbency. Only a few important significant (P<0.05) changes occurred with time. Total peripheral resistance was about 15 per cent lower after two hours of constant dose halothane than after 30 mins of constant dose (P<0.05) and accounted for the significant 10 per cent reduction in mean carotid arterial blood pressure. By 5 h, the reduction in resistance and arterial blood pressure was 20 and 25 per cent respectively. Heart rate increased progressively with time and the increase became significant at 5 h (15 per cent increase). However, the heart rate change was not large enough to alter cardiac output. There were no major time‐related changes in PaO2 or PaCO2. Three of four horses recovered from anaesthesia had markedly elevated serum creatine kinase levels and clinical signs of severe post anaesthetic myopathy.
UR - http://www.scopus.com/inward/record.url?scp=0025522492&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025522492&partnerID=8YFLogxK
U2 - 10.1111/j.2042-3306.1990.tb04311.x
DO - 10.1111/j.2042-3306.1990.tb04311.x
M3 - Article
C2 - 2269268
AN - SCOPUS:0025522492
VL - 22
SP - 433
EP - 436
JO - Equine veterinary journal. Supplement
JF - Equine veterinary journal. Supplement
SN - 2042-3306
IS - 6
ER -