Effects of five hours of constant 1.2 MAC halothane in sternally recumbent, spontaneously breathing horses

Eugene Steffey, M. J. WOLINER, C. DUNLOP

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Circulatory and respiratory effects of five h of constant 1.06 per cent alveolar halothane in oxygen were identified in eight healthy horses, which breathed spontaneously, were otherwise unmedicated and positioned in sternal recumbency. Only a few important significant (P<0.05) changes occurred with time. Total peripheral resistance was about 15 per cent lower after two hours of constant dose halothane than after 30 mins of constant dose (P<0.05) and accounted for the significant 10 per cent reduction in mean carotid arterial blood pressure. By 5 h, the reduction in resistance and arterial blood pressure was 20 and 25 per cent respectively. Heart rate increased progressively with time and the increase became significant at 5 h (15 per cent increase). However, the heart rate change was not large enough to alter cardiac output. There were no major time‐related changes in PaO2 or PaCO2. Three of four horses recovered from anaesthesia had markedly elevated serum creatine kinase levels and clinical signs of severe post anaesthetic myopathy.

Original languageEnglish (US)
Pages (from-to)433-436
Number of pages4
JournalEquine Veterinary Journal
Volume22
Issue number6
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • Equine

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