Effects of fibronectin cleaved by neuropsin on cell adhesion and migration

Naoyuki Tani, Kazumasa Matsumoto, Ichiro Ota, Shigetaka Yoshida, Yoshikazu Takada, Sadao Shiosaka, Nariaki Matsuura

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Neuropsin is a serine protease cloned from the mouse hippocampus. Since neuropsin is a secreted protein which effectively cleaves fibronectin, it may affect cell adhesion or cell migration by modulating the content and/or chemical characteriscs of fibronectin in extracellular matrix (ECM). In adhesion assays, α5B2 cells expressing integrin α5β1 bound less effectively to fibronectin teated with neuropsin than intact fibronectin. In Boyden chamber chemotaxis assays, the fibronectin-induced migration of α5B2 cells was not affected by neuropsin treatment. These findings suggest that neuropsin regulates the local microenvironment by modulating the interaction between cells and fibronectin in ECM.

Original languageEnglish (US)
Pages (from-to)247-251
Number of pages5
JournalNeuroscience Research
Volume39
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Fibronectins
Cell Adhesion
Cell Movement
Extracellular Matrix
Serine Proteases
Chemotaxis
Integrins
Cell Communication
Hippocampus
Proteins

Keywords

  • Cell adhesion
  • Cell migration
  • Fibronectin
  • Neural plasticity
  • Neuropsin
  • Serine protease

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Tani, N., Matsumoto, K., Ota, I., Yoshida, S., Takada, Y., Shiosaka, S., & Matsuura, N. (2001). Effects of fibronectin cleaved by neuropsin on cell adhesion and migration. Neuroscience Research, 39(2), 247-251. https://doi.org/10.1016/S0168-0102(00)00213-3

Effects of fibronectin cleaved by neuropsin on cell adhesion and migration. / Tani, Naoyuki; Matsumoto, Kazumasa; Ota, Ichiro; Yoshida, Shigetaka; Takada, Yoshikazu; Shiosaka, Sadao; Matsuura, Nariaki.

In: Neuroscience Research, Vol. 39, No. 2, 2001, p. 247-251.

Research output: Contribution to journalArticle

Tani, N, Matsumoto, K, Ota, I, Yoshida, S, Takada, Y, Shiosaka, S & Matsuura, N 2001, 'Effects of fibronectin cleaved by neuropsin on cell adhesion and migration', Neuroscience Research, vol. 39, no. 2, pp. 247-251. https://doi.org/10.1016/S0168-0102(00)00213-3
Tani, Naoyuki ; Matsumoto, Kazumasa ; Ota, Ichiro ; Yoshida, Shigetaka ; Takada, Yoshikazu ; Shiosaka, Sadao ; Matsuura, Nariaki. / Effects of fibronectin cleaved by neuropsin on cell adhesion and migration. In: Neuroscience Research. 2001 ; Vol. 39, No. 2. pp. 247-251.
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