TY - JOUR
T1 - Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media
T2 - An experimental and computational study at 337 nm
AU - Papaioannou, Thanassis
AU - Preyer, Norris W.
AU - Fang, Qiyin
AU - Brightwell, Adam
AU - Carnohan, Michael
AU - Cottone, Greg
AU - Ross, Russel
AU - Jones, Linda R.
AU - Marcu, Laura
PY - 2004/5/10
Y1 - 2004/5/10
N2 - Fiber-optic probes are widely used in optical spectroscopy of biological tissues and other turbid media. Only limited information exists, however, on the ways in which the illumination-collection geometry and the overall probe design influence the interrogation of media. We have investigated both experimentally and computationally the effect of probe-to-target distance (PTD) on the diffuse reflectance collected from an isotropically (Lambertian) scattering target and an agar-based tissue phantom. Studies were conducted with three probes characterized by either common (single-fiber) or separate (two bifurcated multifiber probes) illumination and collection channels. This study demonstrates that PTD, probe design, and tissue scattering anisotropy influence the extent of the transport of light into the medium, the light-collection efficiency, and the sampling volume of collected light. The findings can be applied toward optimization of fiber-optic probe designs for quantitative optical spectroscopy of turbid media including biological tissues.
AB - Fiber-optic probes are widely used in optical spectroscopy of biological tissues and other turbid media. Only limited information exists, however, on the ways in which the illumination-collection geometry and the overall probe design influence the interrogation of media. We have investigated both experimentally and computationally the effect of probe-to-target distance (PTD) on the diffuse reflectance collected from an isotropically (Lambertian) scattering target and an agar-based tissue phantom. Studies were conducted with three probes characterized by either common (single-fiber) or separate (two bifurcated multifiber probes) illumination and collection channels. This study demonstrates that PTD, probe design, and tissue scattering anisotropy influence the extent of the transport of light into the medium, the light-collection efficiency, and the sampling volume of collected light. The findings can be applied toward optimization of fiber-optic probe designs for quantitative optical spectroscopy of turbid media including biological tissues.
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U2 - 10.1364/AO.43.002846
DO - 10.1364/AO.43.002846
M3 - Article
C2 - 15143808
AN - SCOPUS:2542500560
VL - 43
SP - 2846
EP - 2860
JO - Applied Optics
JF - Applied Optics
SN - 0003-6935
IS - 14
ER -