Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: An experimental and computational study at 337 nm

Thanassis Papaioannou, Norris W. Preyer, Qiyin Fang, Adam Brightwell, Michael Carnohan, Greg Cottone, Russel Ross, Linda R. Jones, Laura Marcu

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Fiber-optic probes are widely used in optical spectroscopy of biological tissues and other turbid media. Only limited information exists, however, on the ways in which the illumination-collection geometry and the overall probe design influence the interrogation of media. We have investigated both experimentally and computationally the effect of probe-to-target distance (PTD) on the diffuse reflectance collected from an isotropically (Lambertian) scattering target and an agar-based tissue phantom. Studies were conducted with three probes characterized by either common (single-fiber) or separate (two bifurcated multifiber probes) illumination and collection channels. This study demonstrates that PTD, probe design, and tissue scattering anisotropy influence the extent of the transport of light into the medium, the light-collection efficiency, and the sampling volume of collected light. The findings can be applied toward optimization of fiber-optic probe designs for quantitative optical spectroscopy of turbid media including biological tissues.

Original languageEnglish (US)
Pages (from-to)2846-2860
Number of pages15
JournalApplied Optics
Volume43
Issue number14
DOIs
StatePublished - May 10 2004

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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    Papaioannou, T., Preyer, N. W., Fang, Q., Brightwell, A., Carnohan, M., Cottone, G., Ross, R., Jones, L. R., & Marcu, L. (2004). Effects of fiber-optic probe design and probe-to-target distance on diffuse reflectance measurements of turbid media: An experimental and computational study at 337 nm. Applied Optics, 43(14), 2846-2860. https://doi.org/10.1364/AO.43.002846