Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks

Chikoo Oosawa, Kazuhiro Takemoto, Michael A. Savageau

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We demonstrate the advantages of feedforward loops using a Boolean network, which is one of the discrete dynamical models for transcriptional regulatory networks. After comparing the dynamical behaviors of network embedded feedback and feedforward loops, we found that feedforward loops can provide higher temporal order (coherence) with lower entropy (randomness) in a temporal program of gene expression. In addition, complexity of the state space that increases with longer length of attractors and greater number of attractors is also reduced for networks with more feedforward loops. Feedback loops show opposite effects on dynamics of the networks. These results suggest that feedforward loops are one of the favorable local structures in biomolecular and neuronal networks.

Original languageEnglish (US)
Title of host publicationProceedings of the 13th International Symposium on Artificial Life and Robotics, AROB 13th'08
Pages885-890
Number of pages6
StatePublished - 2008
Event13th International Symposium on Artificial Life and Robotics, AROB 13th'08 - Oita, Japan
Duration: Jan 31 2008Feb 2 2008

Other

Other13th International Symposium on Artificial Life and Robotics, AROB 13th'08
CountryJapan
CityOita
Period1/31/082/2/08

Fingerprint

Feedback
Gene expression
Entropy

Keywords

  • Boolean networks
  • Entropy
  • Feedback loop
  • Feedforward loop
  • Mutual information
  • Transcriptional regulatory networks

ASJC Scopus subject areas

  • Artificial Intelligence
  • Computer Vision and Pattern Recognition
  • Human-Computer Interaction

Cite this

Oosawa, C., Takemoto, K., & Savageau, M. A. (2008). Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks. In Proceedings of the 13th International Symposium on Artificial Life and Robotics, AROB 13th'08 (pp. 885-890)

Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks. / Oosawa, Chikoo; Takemoto, Kazuhiro; Savageau, Michael A.

Proceedings of the 13th International Symposium on Artificial Life and Robotics, AROB 13th'08. 2008. p. 885-890.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Oosawa, C, Takemoto, K & Savageau, MA 2008, Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks. in Proceedings of the 13th International Symposium on Artificial Life and Robotics, AROB 13th'08. pp. 885-890, 13th International Symposium on Artificial Life and Robotics, AROB 13th'08, Oita, Japan, 1/31/08.
Oosawa C, Takemoto K, Savageau MA. Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks. In Proceedings of the 13th International Symposium on Artificial Life and Robotics, AROB 13th'08. 2008. p. 885-890
Oosawa, Chikoo ; Takemoto, Kazuhiro ; Savageau, Michael A. / Effects of feedback and feedforward loops on dynamics of transcriptional regulatory model networks. Proceedings of the 13th International Symposium on Artificial Life and Robotics, AROB 13th'08. 2008. pp. 885-890
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