Effects of extended sidestream smoke exposure on components of the C-fiber axon reflex

Jesse P. Joad, Krishna P. Avadhanam, Katherine C. Watt, Kayleen S. Kott, John M. Bric, Kent E Pinkerton

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We have previously shown that young guinea pigs repeatedly exposed to sidestream cigarette smoke (SS) develop decreased airway reactivity of the C-fiber system without changing reactivity to one of its neurotransmitters, substance P (SP). This study was designed to determine whether the decreased reactivity was due to decreased responsiveness to another neurotransmitter, neurokinin A (NKA), decreased lung SP content, decreased affinity or number of NK1 receptors, and/or decreased number of C-fibers. Duncan Hartley guinea pigs were exposed to filtered air (FA) or to SS for 6 h/day, 5 days/week for 5 weeks starting at 1 week of age. SS exposure did not change, (1) airway reactivity to NKA injected into the pulmonary artery of their isolated perfused lungs (n = 6-7 each group), (2) lung SP content as measured by enzyme immunoassay (n = 12 each group), (3) NK1 receptor number or affinity as measured by radioligand binding (n = 7 each group), or (4) SP-immunoreactive nerve profiles of the terminal bronchioles or small airways (n = 6 each group). Thus, SS exposure does not decrease C-fiber system by reducing NKA responsiveness, decreasing SP content, changing NK1 receptors, or decreasing the number of C-fibers.

Original languageEnglish (US)
Pages (from-to)195-203
Number of pages9
Issue number3
StatePublished - Sep 2 1996


  • C-fibers
  • Environmental tobacco smoke
  • Neurokinin A
  • Substance P

ASJC Scopus subject areas

  • Toxicology


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