Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses

Persephone McCrae; Charline Guigand; K. Blythe Jones; Emily S. Thueson; Tristan A. Troudt; Linnea M. Warlick; Raymond H. Sides; James H. Jones; Warwick M. Bayly; Renaud Léguillette

Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses

Persephone McCrae, Charline Guigand, K. Blythe Jones, Emily S. Thueson, Tristan A. Troudt, Linnea M. Warlick, Raymond H. Sides, James H. Jones, Warwick M. Bayly, Renaud Léguillette

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.

Original language	English (US)
Pages (from-to)	1181-1185
Number of pages	5
Journal	The Canadian veterinary journal = La revue veterinaire canadienne
Volume	61
Issue number	11
State	Published - Nov 1 2020

ASJC Scopus subject areas

veterinary(all)

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Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses. / McCrae, Persephone; Guigand, Charline; Jones, K. Blythe; Thueson, Emily S.; Troudt, Tristan A.; Warlick, Linnea M.; Sides, Raymond H.; Jones, James H.; Bayly, Warwick M.; Léguillette, Renaud.

In: The Canadian veterinary journal = La revue veterinaire canadienne, Vol. 61, No. 11, 01.11.2020, p. 1181-1185.

Research output: Contribution to journal › Article › peer-review

McCrae, Persephone ; Guigand, Charline ; Jones, K. Blythe ; Thueson, Emily S. ; Troudt, Tristan A. ; Warlick, Linnea M. ; Sides, Raymond H. ; Jones, James H. ; Bayly, Warwick M. ; Léguillette, Renaud. / Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses. In: The Canadian veterinary journal = La revue veterinaire canadienne. 2020 ; Vol. 61, No. 11. pp. 1181-1185.

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abstract = "High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.",

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AU - Guigand, Charline

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AU - Thueson, Emily S.

AU - Troudt, Tristan A.

AU - Warlick, Linnea M.

AU - Sides, Raymond H.

AU - Jones, James H.

AU - Bayly, Warwick M.

AU - Léguillette, Renaud

N1 - Publisher Copyright: Copyright and/or publishing rights held by the Canadian Veterinary Medical Association. Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

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N2 - High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.

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Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses

Abstract

ASJC Scopus subject areas

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