Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses

Persephone McCrae; Charline Guigand; K. Blythe Jones; Emily S. Thueson; Tristan A. Troudt; Linnea M. Warlick; Raymond H. Sides; James H. Jones; Warwick M. Bayly; Renaud Léguillette

Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses

Persephone McCrae, Charline Guigand, K. Blythe Jones, Emily S. Thueson, Tristan A. Troudt, Linnea M. Warlick, Raymond H. Sides, James H. Jones, Warwick M. Bayly, Renaud Léguillette

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.

Original language	English (US)
Pages (from-to)	1181-1185
Number of pages	5
Journal	The Canadian veterinary journal = La revue veterinaire canadienne
Volume	61
Issue number	11
State	Published - Nov 1 2020

ASJC Scopus subject areas

veterinary(all)

Fingerprint Dive into the research topics of 'Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses'. Together they form a unique fingerprint.

Cite this

Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses. / McCrae, Persephone; Guigand, Charline; Jones, K. Blythe; Thueson, Emily S.; Troudt, Tristan A.; Warlick, Linnea M.; Sides, Raymond H.; Jones, James H.; Bayly, Warwick M.; Léguillette, Renaud.

In: The Canadian veterinary journal = La revue veterinaire canadienne, Vol. 61, No. 11, 01.11.2020, p. 1181-1185.

Research output: Contribution to journal › Article › peer-review

McCrae, Persephone ; Guigand, Charline ; Jones, K. Blythe ; Thueson, Emily S. ; Troudt, Tristan A. ; Warlick, Linnea M. ; Sides, Raymond H. ; Jones, James H. ; Bayly, Warwick M. ; Léguillette, Renaud. / Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses. In: The Canadian veterinary journal = La revue veterinaire canadienne. 2020 ; Vol. 61, No. 11. pp. 1181-1185.

@article{e7b98be2c6834706b035647e8507f937,

title = "Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses",

abstract = "High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.",

author = "Persephone McCrae and Charline Guigand and Jones, {K. Blythe} and Thueson, {Emily S.} and Troudt, {Tristan A.} and Warlick, {Linnea M.} and Sides, {Raymond H.} and Jones, {James H.} and Bayly, {Warwick M.} and Renaud L{\'e}guillette",

note = "Publisher Copyright: Copyright and/or publishing rights held by the Canadian Veterinary Medical Association. Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2020",

month = nov,

day = "1",

language = "English (US)",

volume = "61",

pages = "1181--1185",

journal = "Canadian Veterinary Journal",

issn = "0008-5286",

publisher = "Canadian Veterinary Medical Association",

number = "11",

}

TY - JOUR

T1 - Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses

AU - McCrae, Persephone

AU - Guigand, Charline

AU - Jones, K. Blythe

AU - Thueson, Emily S.

AU - Troudt, Tristan A.

AU - Warlick, Linnea M.

AU - Sides, Raymond H.

AU - Jones, James H.

AU - Bayly, Warwick M.

AU - Léguillette, Renaud

N1 - Publisher Copyright: Copyright and/or publishing rights held by the Canadian Veterinary Medical Association. Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2020/11/1

Y1 - 2020/11/1

N2 - High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.

AB - High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.

UR - http://www.scopus.com/inward/record.url?scp=85095675859&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85095675859&partnerID=8YFLogxK

M3 - Article

C2 - 33149356

AN - SCOPUS:85095675859

VL - 61

SP - 1181

EP - 1185

JO - Canadian Veterinary Journal

JF - Canadian Veterinary Journal

SN - 0008-5286

IS - 11

ER -