Effects of exercise, furosemide, blood depletion, and reinfusion on body fluid compartment volumes in horses

Persephone McCrae, Charline Guigand, K. Blythe Jones, Emily S. Thueson, Tristan A. Troudt, Linnea M. Warlick, Raymond H. Sides, James H. Jones, Warwick M. Bayly, Renaud Léguillette

Research output: Contribution to journalArticlepeer-review

Abstract

High pulmonary blood pressure contributes to exercise-induced pulmonary hemorrhage. The objective of this study was to use bioimpedance spectroscopy to assess body fluid compartment volumes under 3 conditions in 6 racehorses: i) Pre- and post-supramaximal treadmill exercise (control); ii) Exercise 4 hours after furosemide (0.5 mg/kg body weight, IV); iii) Exercise, removal of ~14 L of blood and subsequent reinfusion of the blood. Statistical analysis used linear mixed effects models. Body compartment volumes did not change during the control runs. Total body water (TBW) (P = 0.007, P = 0.007), extracellular fluid (ECF) (P = 0.003, P = 0.003), and intracellular fluid (ICF) volumes (P = 0.04, P = 0.04) decreased pre- and post-exercise following furosemide administration. The ICF trended to decrease (P = 0.07) after slow removal of blood. Blood reinfusion increased TBW (P = 0.02, P = 0.02) and ICF (P = 0.005, P = 0.005) pre- and post-exercise.

Original languageEnglish (US)
Pages (from-to)1181-1185
Number of pages5
JournalThe Canadian veterinary journal = La revue veterinaire canadienne
Volume61
Issue number11
StatePublished - Nov 1 2020

ASJC Scopus subject areas

  • veterinary(all)

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