Abstract
Forty pregnant long-tailed macaques were treated daily for 30 d with 0, 25, 150 or 300 μg selenium as L-selenomethionine/kg body weight. Erythrocyte and plasma selenium and glutathione peroxidase specific activities, hair and fecal selenium, and urinary selenium excretion were increased by and were linearly related to L-selenomethionine dose. Hair selenium was most sensitive to L-selenomethionine dose, with an 84-fold increase in the 300 μg selenium/(kg-d) group relative to controls (r=0.917). Daily urinary selenium excretion (80-fold, r=0.958), plasma selenium (22-fold, r=0.885), erythrocyte selenium (24-fold, r=0.920), and fecal selenium (18-fold, r=0.911) also responded strongly to L-selenomethionine. Erythrocyte and plasma glutathione peroxidase specific activities increased 154% and 69% over controls, respectively. Toxicity was associated with erythrocyte selenium >2.3 μg/mL, plasma selenium >2.8 μg/mL, and hair selenium >27 μg/g. Plasma, erythrocyte, and hair selenium concentrations may be useful for monitoring and preventing the toxicity of L-selenomethionine administered to humans in cancer chemoprevention trials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-297 |
| Number of pages | 17 |
| Journal | Biological Trace Element Research |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| State | Published - Dec 1992 |
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Keywords
- glutathione peroxidase
- long-tailed macaque
- Macaca fascicularis
- nonhuman primate
- selenium
- selenium status assessment
- selenium toxicity, cancer chemoprevention
- Selenomethionine
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Effects of excess selenomethionine on selenium status indicators in pregnant long-tailed macaques (Macaca fascicularis). / Hawkes, Wayne Chris; Willhite, Calvin C.; Craig, Kimberly A.; Omaye, Stanley T.; Cox, Douglas N.; Choy, Wai Nang; Hendrickx, Andrew G.
In: Biological Trace Element Research, Vol. 35, No. 3, 12.1992, p. 281-297.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of excess selenomethionine on selenium status indicators in pregnant long-tailed macaques (Macaca fascicularis)
AU - Hawkes, Wayne Chris
AU - Willhite, Calvin C.
AU - Craig, Kimberly A.
AU - Omaye, Stanley T.
AU - Cox, Douglas N.
AU - Choy, Wai Nang
AU - Hendrickx, Andrew G
PY - 1992/12
Y1 - 1992/12
N2 - Forty pregnant long-tailed macaques were treated daily for 30 d with 0, 25, 150 or 300 μg selenium as L-selenomethionine/kg body weight. Erythrocyte and plasma selenium and glutathione peroxidase specific activities, hair and fecal selenium, and urinary selenium excretion were increased by and were linearly related to L-selenomethionine dose. Hair selenium was most sensitive to L-selenomethionine dose, with an 84-fold increase in the 300 μg selenium/(kg-d) group relative to controls (r=0.917). Daily urinary selenium excretion (80-fold, r=0.958), plasma selenium (22-fold, r=0.885), erythrocyte selenium (24-fold, r=0.920), and fecal selenium (18-fold, r=0.911) also responded strongly to L-selenomethionine. Erythrocyte and plasma glutathione peroxidase specific activities increased 154% and 69% over controls, respectively. Toxicity was associated with erythrocyte selenium >2.3 μg/mL, plasma selenium >2.8 μg/mL, and hair selenium >27 μg/g. Plasma, erythrocyte, and hair selenium concentrations may be useful for monitoring and preventing the toxicity of L-selenomethionine administered to humans in cancer chemoprevention trials.
AB - Forty pregnant long-tailed macaques were treated daily for 30 d with 0, 25, 150 or 300 μg selenium as L-selenomethionine/kg body weight. Erythrocyte and plasma selenium and glutathione peroxidase specific activities, hair and fecal selenium, and urinary selenium excretion were increased by and were linearly related to L-selenomethionine dose. Hair selenium was most sensitive to L-selenomethionine dose, with an 84-fold increase in the 300 μg selenium/(kg-d) group relative to controls (r=0.917). Daily urinary selenium excretion (80-fold, r=0.958), plasma selenium (22-fold, r=0.885), erythrocyte selenium (24-fold, r=0.920), and fecal selenium (18-fold, r=0.911) also responded strongly to L-selenomethionine. Erythrocyte and plasma glutathione peroxidase specific activities increased 154% and 69% over controls, respectively. Toxicity was associated with erythrocyte selenium >2.3 μg/mL, plasma selenium >2.8 μg/mL, and hair selenium >27 μg/g. Plasma, erythrocyte, and hair selenium concentrations may be useful for monitoring and preventing the toxicity of L-selenomethionine administered to humans in cancer chemoprevention trials.
KW - glutathione peroxidase
KW - long-tailed macaque
KW - Macaca fascicularis
KW - nonhuman primate
KW - selenium
KW - selenium status assessment
KW - selenium toxicity, cancer chemoprevention
KW - Selenomethionine
UR - http://www.scopus.com/inward/record.url?scp=0027078641&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027078641&partnerID=8YFLogxK
U2 - 10.1007/BF02783772
DO - 10.1007/BF02783772
M3 - Article
C2 - 1283694
AN - SCOPUS:0027078641
VL - 35
SP - 281
EP - 297
JO - Biological Trace Element Research
JF - Biological Trace Element Research
SN - 0163-4984
IS - 3
ER -