Abstract
Forty pregnant long-tailed macaques were treated daily for 30 d with 0, 25, 150 or 300 μg selenium as L-selenomethionine/kg body weight. Erythrocyte and plasma selenium and glutathione peroxidase specific activities, hair and fecal selenium, and urinary selenium excretion were increased by and were linearly related to L-selenomethionine dose. Hair selenium was most sensitive to L-selenomethionine dose, with an 84-fold increase in the 300 μg selenium/(kg-d) group relative to controls (r=0.917). Daily urinary selenium excretion (80-fold, r=0.958), plasma selenium (22-fold, r=0.885), erythrocyte selenium (24-fold, r=0.920), and fecal selenium (18-fold, r=0.911) also responded strongly to L-selenomethionine. Erythrocyte and plasma glutathione peroxidase specific activities increased 154% and 69% over controls, respectively. Toxicity was associated with erythrocyte selenium >2.3 μg/mL, plasma selenium >2.8 μg/mL, and hair selenium >27 μg/g. Plasma, erythrocyte, and hair selenium concentrations may be useful for monitoring and preventing the toxicity of L-selenomethionine administered to humans in cancer chemoprevention trials.
Original language | English (US) |
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Pages (from-to) | 281-297 |
Number of pages | 17 |
Journal | Biological Trace Element Research |
Volume | 35 |
Issue number | 3 |
DOIs | |
State | Published - Dec 1992 |
Keywords
- glutathione peroxidase
- long-tailed macaque
- Macaca fascicularis
- nonhuman primate
- selenium
- selenium status assessment
- selenium toxicity, cancer chemoprevention
- Selenomethionine
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Endocrinology
- Biochemistry, Genetics and Molecular Biology(all)