Effects of eprosartan on glomerular injury in rats with reduced renal mass

Mehul M Gandhi, Timothy W. Meyer, David P. Brooks

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The effects of the selective angiotensin AT1 receptor antagonist, eprosartan, were evaluated in experimental renal disease. Five-sixth nephrectomy in male Munich-Wistar rats led to the development of hypertension, proteinuria and remnant glomerulosclerosis. Administration of the AT1 receptor antagonist, eprosartan, for 4 weeks resulted in inhibition of angiotensin II activity as confirmed by a reduced blood pressure response to exogenous angiotensin II challenge. Compared to vehicle treatment, eprosartan normalized blood pressure, reduced proteinuria and limited remnant glomerulosclerosis. These data suggest that eprosartan may provide a new tool in the treatment of progressive renal disease.

Original languageEnglish (US)
Pages (from-to)89-94
Number of pages6
JournalPharmacology
Volume59
Issue number2
DOIs
StatePublished - Aug 1999
Externally publishedYes

    Fingerprint

Keywords

  • Angiotensin II
  • Glomerulosclerosis
  • Hypertension
  • Proteinuria

ASJC Scopus subject areas

  • Pharmacology

Cite this