Effects of epidurally administered morphine or buprenorphine on the thermal threshold in cats

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Abstract

Objective - To determine the antinociceptive effects of epidural administration of morphine or buprenorphine in cats by use of a thermal threshold model. Animals - 6 healthy adult cats. Procedures - Baseline thermal threshold was determined in duplicate. Cats were anesthetized with isoflurane in oxygen. Morphine (100 μg/kg diluted with saline [0.9% NaCl] solution to a total volume of 0.3 mL/ kg), buprenorphine (12.5 μg/kg diluted with saline solution to a total volume of 0.3 mL/kg), or saline solution (0.3 mL/kg) was administered into the epidural space according to a Latin square design. Thermal threshold was determined at various times up to 24 hours after epidural injection. Results - Epidural administration of saline solution did not affect thermal threshold. Thermal threshold was significantly higher after epidural administration of morphine and buprenorphine, compared with the effect of saline solution, from 1 to 16 hours and 1 to 10 hours, respectively. Maximum (cutout) temperature was reached without the cat reacting in 0, 74, and 11 occasions in the saline solution, morphine, and buprenorphine groups, respectively. Conclusions and Clinical Relevance - Epidural administration of morphine and buprenorphine induced thermal antinociception in cats. At the doses used in this study, the effect of morphine lasted longer and was more intense than that of buprenorphine.

Original languageEnglish (US)
Pages (from-to)983-987
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume69
Issue number8
DOIs
StatePublished - Aug 2008

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buprenorphine
Buprenorphine
morphine
sodium chloride
Morphine
Cats
Sodium Chloride
Hot Temperature
cats
heat
Epidural Injections
Epidural Space
analgesic effect
Isoflurane
isoflurane
Oxygen
injection
oxygen
Temperature
dosage

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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title = "Effects of epidurally administered morphine or buprenorphine on the thermal threshold in cats",
abstract = "Objective - To determine the antinociceptive effects of epidural administration of morphine or buprenorphine in cats by use of a thermal threshold model. Animals - 6 healthy adult cats. Procedures - Baseline thermal threshold was determined in duplicate. Cats were anesthetized with isoflurane in oxygen. Morphine (100 μg/kg diluted with saline [0.9{\%} NaCl] solution to a total volume of 0.3 mL/ kg), buprenorphine (12.5 μg/kg diluted with saline solution to a total volume of 0.3 mL/kg), or saline solution (0.3 mL/kg) was administered into the epidural space according to a Latin square design. Thermal threshold was determined at various times up to 24 hours after epidural injection. Results - Epidural administration of saline solution did not affect thermal threshold. Thermal threshold was significantly higher after epidural administration of morphine and buprenorphine, compared with the effect of saline solution, from 1 to 16 hours and 1 to 10 hours, respectively. Maximum (cutout) temperature was reached without the cat reacting in 0, 74, and 11 occasions in the saline solution, morphine, and buprenorphine groups, respectively. Conclusions and Clinical Relevance - Epidural administration of morphine and buprenorphine induced thermal antinociception in cats. At the doses used in this study, the effect of morphine lasted longer and was more intense than that of buprenorphine.",
author = "Pypendop, {Bruno H} and Siao, {Kristine T.} and Pascoe, {Peter J} and Jan Ilkiw",
year = "2008",
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AU - Siao, Kristine T.

AU - Pascoe, Peter J

AU - Ilkiw, Jan

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N2 - Objective - To determine the antinociceptive effects of epidural administration of morphine or buprenorphine in cats by use of a thermal threshold model. Animals - 6 healthy adult cats. Procedures - Baseline thermal threshold was determined in duplicate. Cats were anesthetized with isoflurane in oxygen. Morphine (100 μg/kg diluted with saline [0.9% NaCl] solution to a total volume of 0.3 mL/ kg), buprenorphine (12.5 μg/kg diluted with saline solution to a total volume of 0.3 mL/kg), or saline solution (0.3 mL/kg) was administered into the epidural space according to a Latin square design. Thermal threshold was determined at various times up to 24 hours after epidural injection. Results - Epidural administration of saline solution did not affect thermal threshold. Thermal threshold was significantly higher after epidural administration of morphine and buprenorphine, compared with the effect of saline solution, from 1 to 16 hours and 1 to 10 hours, respectively. Maximum (cutout) temperature was reached without the cat reacting in 0, 74, and 11 occasions in the saline solution, morphine, and buprenorphine groups, respectively. Conclusions and Clinical Relevance - Epidural administration of morphine and buprenorphine induced thermal antinociception in cats. At the doses used in this study, the effect of morphine lasted longer and was more intense than that of buprenorphine.

AB - Objective - To determine the antinociceptive effects of epidural administration of morphine or buprenorphine in cats by use of a thermal threshold model. Animals - 6 healthy adult cats. Procedures - Baseline thermal threshold was determined in duplicate. Cats were anesthetized with isoflurane in oxygen. Morphine (100 μg/kg diluted with saline [0.9% NaCl] solution to a total volume of 0.3 mL/ kg), buprenorphine (12.5 μg/kg diluted with saline solution to a total volume of 0.3 mL/kg), or saline solution (0.3 mL/kg) was administered into the epidural space according to a Latin square design. Thermal threshold was determined at various times up to 24 hours after epidural injection. Results - Epidural administration of saline solution did not affect thermal threshold. Thermal threshold was significantly higher after epidural administration of morphine and buprenorphine, compared with the effect of saline solution, from 1 to 16 hours and 1 to 10 hours, respectively. Maximum (cutout) temperature was reached without the cat reacting in 0, 74, and 11 occasions in the saline solution, morphine, and buprenorphine groups, respectively. Conclusions and Clinical Relevance - Epidural administration of morphine and buprenorphine induced thermal antinociception in cats. At the doses used in this study, the effect of morphine lasted longer and was more intense than that of buprenorphine.

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