Effects of environmental tobacco smoke in vivo on rhesus monkey semen quality, sperm function, and sperm metabolism

Pei hsuan Hung, Lutz Froenicke, Ching Yu Lin, Leslie A Lyons, Marion G. Miller, Kent E Pinkerton, Catherine A. VandeVoort

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The objective of this study was to use a non-human primate model to examine the effect of environmental tobacco smoke (ETS) in vivo on semen quality, sperm function, and sperm metabolism. Four adult rhesus macaques (Macaca mulatta) were exposed to ETS for six months, and semen samples were collected every week for evaluation. ETS exposure in vivo did not affect semen quality and sperm function. The sperm X:Y chromosome ratio remained unchanged after ETS exposure. The sex ratio of the embryos fertilized by ETS-exposed males was not different from the control male. However, sperm showed changes in metabolome detected by NMR during the ETS exposure. We concluded that with the duration and level of ETS exposure in this study, semen quality and sperm function were not affected, whereas sperm did undergo metabolic changes with ETS exposure in vivo.

Original languageEnglish (US)
Pages (from-to)140-148
Number of pages9
JournalReproductive Toxicology
Volume27
Issue number2
DOIs
StatePublished - Apr 2009

Fingerprint

Semen Analysis
Tobacco
Macaca mulatta
Metabolism
Smoke
Spermatozoa
Metabolome
Y Chromosome
Sex Ratio
X Chromosome
Chromosomes
Semen
Primates
Embryonic Structures
Nuclear magnetic resonance

Keywords

  • Embryo sex typing
  • Environmental tobacco smoke
  • Male reproduction
  • Non-human primate
  • Semen quality
  • Sperm metabolomics
  • Sperm motility
  • Sperm X:Y ratio

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of environmental tobacco smoke in vivo on rhesus monkey semen quality, sperm function, and sperm metabolism. / Hung, Pei hsuan; Froenicke, Lutz; Lin, Ching Yu; Lyons, Leslie A; Miller, Marion G.; Pinkerton, Kent E; VandeVoort, Catherine A.

In: Reproductive Toxicology, Vol. 27, No. 2, 04.2009, p. 140-148.

Research output: Contribution to journalArticle

Hung, Pei hsuan ; Froenicke, Lutz ; Lin, Ching Yu ; Lyons, Leslie A ; Miller, Marion G. ; Pinkerton, Kent E ; VandeVoort, Catherine A. / Effects of environmental tobacco smoke in vivo on rhesus monkey semen quality, sperm function, and sperm metabolism. In: Reproductive Toxicology. 2009 ; Vol. 27, No. 2. pp. 140-148.
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