Abstract
The objective of this study was to use a non-human primate model to examine the effect of ETS on sperm function. Sperm samples were collected from adult rhesus monkeys (Macaca mulatta) and treated with different levels of ETS exposed medium. ETS treatment decreased the percentage of motile sperm and motion parameters. Sperm treated with ETS exposed medium showed a limited response to the activators and exhibited decreased binding to the zonae pellucida after activation. The mitochondrial integrity of the ETS-treated sperm was disrupted; however, there was no decrease in viability compared to control groups. Sperm acrosomal status was similar in the control and treatment groups. The results imply that the exposure of primate sperm to ETS could impair sperm transport in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 499-506 |
| Number of pages | 8 |
| Journal | Reproductive Toxicology |
| Volume | 23 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 2007 |
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Keywords
- Acrosome reaction
- Environmental tobacco smoke
- In vitro
- Non-human primate
- Reproduction
- Rhesus macaque
- Sperm
- Sperm motility
ASJC Scopus subject areas
- Toxicology
Cite this
Effects of environmental tobacco smoke in vitro on rhesus monkey sperm function. / Hung, Pei Hsuan; Baumber, Julie; Meyers, Stuart A; VandeVoort, Catherine A.
In: Reproductive Toxicology, Vol. 23, No. 4, 06.2007, p. 499-506.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of environmental tobacco smoke in vitro on rhesus monkey sperm function
AU - Hung, Pei Hsuan
AU - Baumber, Julie
AU - Meyers, Stuart A
AU - VandeVoort, Catherine A.
PY - 2007/6
Y1 - 2007/6
N2 - The objective of this study was to use a non-human primate model to examine the effect of ETS on sperm function. Sperm samples were collected from adult rhesus monkeys (Macaca mulatta) and treated with different levels of ETS exposed medium. ETS treatment decreased the percentage of motile sperm and motion parameters. Sperm treated with ETS exposed medium showed a limited response to the activators and exhibited decreased binding to the zonae pellucida after activation. The mitochondrial integrity of the ETS-treated sperm was disrupted; however, there was no decrease in viability compared to control groups. Sperm acrosomal status was similar in the control and treatment groups. The results imply that the exposure of primate sperm to ETS could impair sperm transport in vivo.
AB - The objective of this study was to use a non-human primate model to examine the effect of ETS on sperm function. Sperm samples were collected from adult rhesus monkeys (Macaca mulatta) and treated with different levels of ETS exposed medium. ETS treatment decreased the percentage of motile sperm and motion parameters. Sperm treated with ETS exposed medium showed a limited response to the activators and exhibited decreased binding to the zonae pellucida after activation. The mitochondrial integrity of the ETS-treated sperm was disrupted; however, there was no decrease in viability compared to control groups. Sperm acrosomal status was similar in the control and treatment groups. The results imply that the exposure of primate sperm to ETS could impair sperm transport in vivo.
KW - Acrosome reaction
KW - Environmental tobacco smoke
KW - In vitro
KW - Non-human primate
KW - Reproduction
KW - Rhesus macaque
KW - Sperm
KW - Sperm motility
UR - http://www.scopus.com/inward/record.url?scp=34248523314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248523314&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2007.03.005
DO - 10.1016/j.reprotox.2007.03.005
M3 - Article
C2 - 17499478
AN - SCOPUS:34248523314
VL - 23
SP - 499
EP - 506
JO - Reproductigve Toxicoloy
JF - Reproductigve Toxicoloy
SN - 0890-6238
IS - 4
ER -