Effects of environmental tobacco smoke in vitro on rhesus monkey sperm function

Pei Hsuan Hung; Julie Baumber; Stuart A Meyers; Catherine A. VandeVoort

doi:10.1016/j.reprotox.2007.03.005

Effects of environmental tobacco smoke in vitro on rhesus monkey sperm function

Pei Hsuan Hung, Julie Baumber, Stuart A Meyers, Catherine A. VandeVoort

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The objective of this study was to use a non-human primate model to examine the effect of ETS on sperm function. Sperm samples were collected from adult rhesus monkeys (Macaca mulatta) and treated with different levels of ETS exposed medium. ETS treatment decreased the percentage of motile sperm and motion parameters. Sperm treated with ETS exposed medium showed a limited response to the activators and exhibited decreased binding to the zonae pellucida after activation. The mitochondrial integrity of the ETS-treated sperm was disrupted; however, there was no decrease in viability compared to control groups. Sperm acrosomal status was similar in the control and treatment groups. The results imply that the exposure of primate sperm to ETS could impair sperm transport in vivo.

Original language	English (US)
Pages (from-to)	499-506
Number of pages	8
Journal	Reproductive Toxicology
Volume	23
Issue number	4
DOIs	https://doi.org/10.1016/j.reprotox.2007.03.005
State	Published - Jun 2007

Keywords

Acrosome reaction
Environmental tobacco smoke
In vitro
Non-human primate
Reproduction
Rhesus macaque
Sperm
Sperm motility

ASJC Scopus subject areas

Toxicology

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10.1016/j.reprotox.2007.03.005

Cite this

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title = "Effects of environmental tobacco smoke in vitro on rhesus monkey sperm function",

abstract = "The objective of this study was to use a non-human primate model to examine the effect of ETS on sperm function. Sperm samples were collected from adult rhesus monkeys (Macaca mulatta) and treated with different levels of ETS exposed medium. ETS treatment decreased the percentage of motile sperm and motion parameters. Sperm treated with ETS exposed medium showed a limited response to the activators and exhibited decreased binding to the zonae pellucida after activation. The mitochondrial integrity of the ETS-treated sperm was disrupted; however, there was no decrease in viability compared to control groups. Sperm acrosomal status was similar in the control and treatment groups. The results imply that the exposure of primate sperm to ETS could impair sperm transport in vivo.",

keywords = "Acrosome reaction, Environmental tobacco smoke, In vitro, Non-human primate, Reproduction, Rhesus macaque, Sperm, Sperm motility",

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AU - Hung, Pei Hsuan

AU - Baumber, Julie

AU - Meyers, Stuart A

AU - VandeVoort, Catherine A.

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Y1 - 2007/6

N2 - The objective of this study was to use a non-human primate model to examine the effect of ETS on sperm function. Sperm samples were collected from adult rhesus monkeys (Macaca mulatta) and treated with different levels of ETS exposed medium. ETS treatment decreased the percentage of motile sperm and motion parameters. Sperm treated with ETS exposed medium showed a limited response to the activators and exhibited decreased binding to the zonae pellucida after activation. The mitochondrial integrity of the ETS-treated sperm was disrupted; however, there was no decrease in viability compared to control groups. Sperm acrosomal status was similar in the control and treatment groups. The results imply that the exposure of primate sperm to ETS could impair sperm transport in vivo.

AB - The objective of this study was to use a non-human primate model to examine the effect of ETS on sperm function. Sperm samples were collected from adult rhesus monkeys (Macaca mulatta) and treated with different levels of ETS exposed medium. ETS treatment decreased the percentage of motile sperm and motion parameters. Sperm treated with ETS exposed medium showed a limited response to the activators and exhibited decreased binding to the zonae pellucida after activation. The mitochondrial integrity of the ETS-treated sperm was disrupted; however, there was no decrease in viability compared to control groups. Sperm acrosomal status was similar in the control and treatment groups. The results imply that the exposure of primate sperm to ETS could impair sperm transport in vivo.

KW - Acrosome reaction

KW - Environmental tobacco smoke

KW - In vitro

KW - Non-human primate

KW - Reproduction

KW - Rhesus macaque

KW - Sperm

KW - Sperm motility

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Effects of environmental tobacco smoke in vitro on rhesus monkey sperm function

Abstract

Keywords

ASJC Scopus subject areas

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