Effects of EGTA on the calcium-activated afterhyperpolarization in hippocampal CA3 pyramidal cells

Philip A Schwartzkroin, Carl E. Stafstrom

Research output: Contribution to journalArticle

180 Scopus citations

Abstract

Intracellular recordings in the hippocampal slice preparation were made with electrodes filled with 0.2 molar potassium EGTA. The purpose was to investigate the role of calcium in mediating afterhyperpolarizations following bursts evoked by intracellular current pulses, arising spontaneously, or induced by the epileptogenic agent penicillin. In the first two cases the afterhyperpolarization was blocked and the associated conductance increase was reduced, suggesting that EGTA was blocking the calcium-activated potassium conductance during the hyperpolarization. In the third case the afterhyperpolarization and associated conductance increase persisted, implicating an alternative mechanism for the hyperpolarization.

Original languageEnglish (US)
Pages (from-to)1125-1126
Number of pages2
JournalScience
Volume210
Issue number4474
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

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