Effects of early postnatal growth restriction and subsequent catch-up growth on body composition, insulin sensitivity, and behavior in neonatal rats

Ming Yu Jou, Bo Lönnerdal, Ian J. Griffin

Research output: Contribution to journalArticle

14 Scopus citations


Background: Early postnatal growth retardation with subsequent catch-up growth is common in preterm infants. We describe a model of ex utero (postnatal) growth retardation followed by varying degrees of catch-up growth in the neonatal rat. Methods: Newborn CD rat pups were randomized to litters of 10 (NN, normal then normal intake) or 16 (R, restricted intake). On day 10, R pups were further randomized to litters of 6 (RC, restricted then catch-up intake), 10 (RN, restricted then normal intake), or 16 (RR, restricted then restricted intake). Body weight, body composition, insulin sensitivity, biochemistry, and learning (passive avoidance test) were assessed. Results: Growth was significantly lower in the R than the NN group. Subsequently, the RC group caught up with the NN group but had higher fat mass; the RN group showed partial catch-up but body composition similar to that of the NN group. Insulin sensitivity did not differ between groups. Learning behavior was significantly better in the NN than the three R groups, and in the RC group than the RR or RN groups. Conclusion: Early postnatal growth retardation is associated with poorer medium-term growth and poorer developmental outcome. Increased catch-up growth is associated with improved developmental outcome but with increased body adiposity, without any significant effect on glucose homeostasis.

Original languageEnglish (US)
Pages (from-to)596-601
Number of pages6
JournalPediatric Research
Issue number5
StatePublished - May 2013


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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