Effects of early postnatal growth restriction and subsequent catch-up growth on body composition, insulin sensitivity, and behavior in neonatal rats

Ming Yu Jou, Bo Lönnerdal, Ian J. Griffin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Early postnatal growth retardation with subsequent catch-up growth is common in preterm infants. We describe a model of ex utero (postnatal) growth retardation followed by varying degrees of catch-up growth in the neonatal rat. Methods: Newborn CD rat pups were randomized to litters of 10 (NN, normal then normal intake) or 16 (R, restricted intake). On day 10, R pups were further randomized to litters of 6 (RC, restricted then catch-up intake), 10 (RN, restricted then normal intake), or 16 (RR, restricted then restricted intake). Body weight, body composition, insulin sensitivity, biochemistry, and learning (passive avoidance test) were assessed. Results: Growth was significantly lower in the R than the NN group. Subsequently, the RC group caught up with the NN group but had higher fat mass; the RN group showed partial catch-up but body composition similar to that of the NN group. Insulin sensitivity did not differ between groups. Learning behavior was significantly better in the NN than the three R groups, and in the RC group than the RR or RN groups. Conclusion: Early postnatal growth retardation is associated with poorer medium-term growth and poorer developmental outcome. Increased catch-up growth is associated with improved developmental outcome but with increased body adiposity, without any significant effect on glucose homeostasis.

Original languageEnglish (US)
Pages (from-to)596-601
Number of pages6
JournalPediatric Research
Volume73
Issue number5
DOIs
StatePublished - May 2013

Fingerprint

Body Composition
Insulin Resistance
Growth
Avoidance Learning
Adiposity
Premature Infants
Biochemistry
Homeostasis
Fats
Body Weight
Learning
Newborn Infant
Glucose

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Effects of early postnatal growth restriction and subsequent catch-up growth on body composition, insulin sensitivity, and behavior in neonatal rats. / Jou, Ming Yu; Lönnerdal, Bo; Griffin, Ian J.

In: Pediatric Research, Vol. 73, No. 5, 05.2013, p. 596-601.

Research output: Contribution to journalArticle

@article{91f6fff2a90748d1917ab9d03aa19b6f,
title = "Effects of early postnatal growth restriction and subsequent catch-up growth on body composition, insulin sensitivity, and behavior in neonatal rats",
abstract = "Background: Early postnatal growth retardation with subsequent catch-up growth is common in preterm infants. We describe a model of ex utero (postnatal) growth retardation followed by varying degrees of catch-up growth in the neonatal rat. Methods: Newborn CD rat pups were randomized to litters of 10 (NN, normal then normal intake) or 16 (R, restricted intake). On day 10, R pups were further randomized to litters of 6 (RC, restricted then catch-up intake), 10 (RN, restricted then normal intake), or 16 (RR, restricted then restricted intake). Body weight, body composition, insulin sensitivity, biochemistry, and learning (passive avoidance test) were assessed. Results: Growth was significantly lower in the R than the NN group. Subsequently, the RC group caught up with the NN group but had higher fat mass; the RN group showed partial catch-up but body composition similar to that of the NN group. Insulin sensitivity did not differ between groups. Learning behavior was significantly better in the NN than the three R groups, and in the RC group than the RR or RN groups. Conclusion: Early postnatal growth retardation is associated with poorer medium-term growth and poorer developmental outcome. Increased catch-up growth is associated with improved developmental outcome but with increased body adiposity, without any significant effect on glucose homeostasis.",
author = "Jou, {Ming Yu} and Bo L{\"o}nnerdal and Griffin, {Ian J.}",
year = "2013",
month = "5",
doi = "10.1038/pr.2013.27",
language = "English (US)",
volume = "73",
pages = "596--601",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Effects of early postnatal growth restriction and subsequent catch-up growth on body composition, insulin sensitivity, and behavior in neonatal rats

AU - Jou, Ming Yu

AU - Lönnerdal, Bo

AU - Griffin, Ian J.

PY - 2013/5

Y1 - 2013/5

N2 - Background: Early postnatal growth retardation with subsequent catch-up growth is common in preterm infants. We describe a model of ex utero (postnatal) growth retardation followed by varying degrees of catch-up growth in the neonatal rat. Methods: Newborn CD rat pups were randomized to litters of 10 (NN, normal then normal intake) or 16 (R, restricted intake). On day 10, R pups were further randomized to litters of 6 (RC, restricted then catch-up intake), 10 (RN, restricted then normal intake), or 16 (RR, restricted then restricted intake). Body weight, body composition, insulin sensitivity, biochemistry, and learning (passive avoidance test) were assessed. Results: Growth was significantly lower in the R than the NN group. Subsequently, the RC group caught up with the NN group but had higher fat mass; the RN group showed partial catch-up but body composition similar to that of the NN group. Insulin sensitivity did not differ between groups. Learning behavior was significantly better in the NN than the three R groups, and in the RC group than the RR or RN groups. Conclusion: Early postnatal growth retardation is associated with poorer medium-term growth and poorer developmental outcome. Increased catch-up growth is associated with improved developmental outcome but with increased body adiposity, without any significant effect on glucose homeostasis.

AB - Background: Early postnatal growth retardation with subsequent catch-up growth is common in preterm infants. We describe a model of ex utero (postnatal) growth retardation followed by varying degrees of catch-up growth in the neonatal rat. Methods: Newborn CD rat pups were randomized to litters of 10 (NN, normal then normal intake) or 16 (R, restricted intake). On day 10, R pups were further randomized to litters of 6 (RC, restricted then catch-up intake), 10 (RN, restricted then normal intake), or 16 (RR, restricted then restricted intake). Body weight, body composition, insulin sensitivity, biochemistry, and learning (passive avoidance test) were assessed. Results: Growth was significantly lower in the R than the NN group. Subsequently, the RC group caught up with the NN group but had higher fat mass; the RN group showed partial catch-up but body composition similar to that of the NN group. Insulin sensitivity did not differ between groups. Learning behavior was significantly better in the NN than the three R groups, and in the RC group than the RR or RN groups. Conclusion: Early postnatal growth retardation is associated with poorer medium-term growth and poorer developmental outcome. Increased catch-up growth is associated with improved developmental outcome but with increased body adiposity, without any significant effect on glucose homeostasis.

UR - http://www.scopus.com/inward/record.url?scp=84879107211&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879107211&partnerID=8YFLogxK

U2 - 10.1038/pr.2013.27

DO - 10.1038/pr.2013.27

M3 - Article

C2 - 23466481

AN - SCOPUS:84879107211

VL - 73

SP - 596

EP - 601

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 5

ER -