Abstract
Platelet function and fatty acid composition were investigated in 30 healthy male subjects who ate a controlled-saturated-fatty-acid (baseline) diet for 3 wk and then consumed either safflower oil or canola oil as a major fat source for 8 wk. Fatty acid composition of platelet phospholipids reflected changes in dietary fatty acid composition. Compared with baseline a 35% decrease (P < 0.05) in arachidonic acid was observed in platelet phospholipids of the canola-oil diet group while long chain n-3 fatty acids rose 7-26% (P > 0.05). Compared with baseline both unsaturated-fatty-acid diets reduced platelet aggregation at 3 wk of oil-based diet feeding (P < 0.01) whereas only canola oil influenced platelet function (lowered ATP secretion) at 8 wk (P < 0.01). No significant difference was observed in thromboxane B2 concentrations between oil-treatment groups at 8 wk. Both oil-based diets had short-term beneficial effects on platelet function but the effect of canola oil persisted longer.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 351-358 |
| Number of pages | 8 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 54 |
| Issue number | 2 |
| State | Published - Aug 1991 |
| Externally published | Yes |
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Keywords
- α-linolenic acid
- Arachidonic acid
- Canola oil
- Dietary fatty acids
- Platelet aggregation
- Platelet phospholipid fatty acids
- Safflower oil
ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
Cite this
Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids. / Kwon, Jong Sook; Snook, Jean T.; Wardlaw, Gordon M.; Hwang, Daniel H.
In: American Journal of Clinical Nutrition, Vol. 54, No. 2, 08.1991, p. 351-358.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of diets high in saturated fatty acids, canola oil, or safflower oil on platelet function, thromboxane B2 formation, and fatty acid composition of platelet phospholipids
AU - Kwon, Jong Sook
AU - Snook, Jean T.
AU - Wardlaw, Gordon M.
AU - Hwang, Daniel H.
PY - 1991/8
Y1 - 1991/8
N2 - Platelet function and fatty acid composition were investigated in 30 healthy male subjects who ate a controlled-saturated-fatty-acid (baseline) diet for 3 wk and then consumed either safflower oil or canola oil as a major fat source for 8 wk. Fatty acid composition of platelet phospholipids reflected changes in dietary fatty acid composition. Compared with baseline a 35% decrease (P < 0.05) in arachidonic acid was observed in platelet phospholipids of the canola-oil diet group while long chain n-3 fatty acids rose 7-26% (P > 0.05). Compared with baseline both unsaturated-fatty-acid diets reduced platelet aggregation at 3 wk of oil-based diet feeding (P < 0.01) whereas only canola oil influenced platelet function (lowered ATP secretion) at 8 wk (P < 0.01). No significant difference was observed in thromboxane B2 concentrations between oil-treatment groups at 8 wk. Both oil-based diets had short-term beneficial effects on platelet function but the effect of canola oil persisted longer.
AB - Platelet function and fatty acid composition were investigated in 30 healthy male subjects who ate a controlled-saturated-fatty-acid (baseline) diet for 3 wk and then consumed either safflower oil or canola oil as a major fat source for 8 wk. Fatty acid composition of platelet phospholipids reflected changes in dietary fatty acid composition. Compared with baseline a 35% decrease (P < 0.05) in arachidonic acid was observed in platelet phospholipids of the canola-oil diet group while long chain n-3 fatty acids rose 7-26% (P > 0.05). Compared with baseline both unsaturated-fatty-acid diets reduced platelet aggregation at 3 wk of oil-based diet feeding (P < 0.01) whereas only canola oil influenced platelet function (lowered ATP secretion) at 8 wk (P < 0.01). No significant difference was observed in thromboxane B2 concentrations between oil-treatment groups at 8 wk. Both oil-based diets had short-term beneficial effects on platelet function but the effect of canola oil persisted longer.
KW - α-linolenic acid
KW - Arachidonic acid
KW - Canola oil
KW - Dietary fatty acids
KW - Platelet aggregation
KW - Platelet phospholipid fatty acids
KW - Safflower oil
UR - http://www.scopus.com/inward/record.url?scp=0025863979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025863979&partnerID=8YFLogxK
M3 - Article
C2 - 1677525
AN - SCOPUS:0025863979
VL - 54
SP - 351
EP - 358
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 2
ER -