Effects of dietary magnesium on fructose-induced insulin resistance and hypertriglyceridemia in hamsters

Siddika E Karakas, Rogelio U. Almario, Ismail Temel

Research output: Contribution to journalArticle

3 Scopus citations


Fructose (FR)-feeding has been used to induce insulin resistance, hypertriglyceridemia and hypertension in rats, and recently in hamsters. As compared to chow, the semi-purified diet currently recommended by the American Institute of Nutrition (AIN) contains less magnesium. It was recently proposed that metabolic changes caused by carbohydrate-rich semipurified diets are due to their low magnesium contents. We tested the effects of two FR-rich (30%, w/w) diets containing either 520 mg/kg (FR-AIN) or 2100 mg/kg magnesium (HI-MG-FR-AIN) in Golden Syrian hamsters. After two weeks of feeding, HI-MG-FR-AIN group had higher plasma magnesium levels (1.57±0.0.5 mmol/L vs 1.31±0.07 mmol/L, p < 0.05). However, both groups developed comparable levels of hyperglycemia, hyperinsulinemia and hypertriglyceridemia. These findings suggest that the metabolic changes induced by FR-rich semi-purified diets are not due to their low magnesium contents.

Original languageEnglish (US)
Pages (from-to)713-719
Number of pages7
JournalNutrition Research
Issue number4
StatePublished - Apr 1997
Externally publishedYes



  • Fructose
  • hamster
  • hypertriglyceridemia
  • insulin-resistance
  • magnesium

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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