Effects of dietary lysine supplementation on upper respiratory and ocular disease and detection of infectious organisms in cats within an animal shelter

Tracy L. Drazenovich, Andrea J Fascetti, Hans D. Westermeyer, Jane E Sykes, Mike J. Bannasch, Philip H Kass, Kate F. Hurley, David J Maggs

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective - To determine within a cat shelter effects of dietary lysine supplementation on nasal and ocular disease and detection of nucleic acids of Chlamydophila felis, feline calicivirus (FCV), and feline herpesvirus (FHV-1). Animals - 261 adult cats. Procedures - Cats were fed a diet containing 1.7% (basal diet; control cats) or 5.7% (supplemented diet; treated cats) lysine for 4 weeks. Plasma concentrations of lysine and arginine were assessed at the beginning (baseline) and end of the study. Three times a week, cats were assigned a clinical score based on evidence of nasal and ocular disease. Conjunctival and oropharyngeal swab specimens were tested for FHV-1, FCV, and C felis nucleic acids once a week. Results - Data were collected from 123, 74, 59, and 47 cats during study weeks 1, 2, 3, and 4, respectively. By study end, plasma lysine concentration in treated cats was greater than that in control cats and had increased from baseline. There was no difference between dietary groups in the proportion of cats developing mild disease. However, more treated cats than control cats developed moderate to severe disease during week 4. During week 2, FHV-1 DNA was detected more commonly in swab specimens from treated versus control cats. Conclusions and Clinical Relevance - Dietary lysine supplementation in the amount used in our study was not a successful means of controlling infectious upper respiratory disease within a cat shelter. Rather, it led to increases in disease severity and the incidence of detection of FHV-1 DNA in oropharyngeal or conjunctival mucosal swab specimens at certain time points.

Original languageEnglish (US)
Pages (from-to)1391-1400
Number of pages10
JournalAmerican Journal of Veterinary Research
Volume70
Issue number11
DOIs
StatePublished - Nov 2009

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eye diseases
Eye Diseases
Dietary Supplements
respiratory tract diseases
Lysine
lysine
Cats
cats
organisms
animals
Feline Calicivirus
Felis
Nose Diseases
Feline calicivirus
Diet
Nucleic Acids
nucleic acids
Chlamydophila
Chlamydophila felis
diet

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Effects of dietary lysine supplementation on upper respiratory and ocular disease and detection of infectious organisms in cats within an animal shelter. / Drazenovich, Tracy L.; Fascetti, Andrea J; Westermeyer, Hans D.; Sykes, Jane E; Bannasch, Mike J.; Kass, Philip H; Hurley, Kate F.; Maggs, David J.

In: American Journal of Veterinary Research, Vol. 70, No. 11, 11.2009, p. 1391-1400.

Research output: Contribution to journalArticle

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abstract = "Objective - To determine within a cat shelter effects of dietary lysine supplementation on nasal and ocular disease and detection of nucleic acids of Chlamydophila felis, feline calicivirus (FCV), and feline herpesvirus (FHV-1). Animals - 261 adult cats. Procedures - Cats were fed a diet containing 1.7{\%} (basal diet; control cats) or 5.7{\%} (supplemented diet; treated cats) lysine for 4 weeks. Plasma concentrations of lysine and arginine were assessed at the beginning (baseline) and end of the study. Three times a week, cats were assigned a clinical score based on evidence of nasal and ocular disease. Conjunctival and oropharyngeal swab specimens were tested for FHV-1, FCV, and C felis nucleic acids once a week. Results - Data were collected from 123, 74, 59, and 47 cats during study weeks 1, 2, 3, and 4, respectively. By study end, plasma lysine concentration in treated cats was greater than that in control cats and had increased from baseline. There was no difference between dietary groups in the proportion of cats developing mild disease. However, more treated cats than control cats developed moderate to severe disease during week 4. During week 2, FHV-1 DNA was detected more commonly in swab specimens from treated versus control cats. Conclusions and Clinical Relevance - Dietary lysine supplementation in the amount used in our study was not a successful means of controlling infectious upper respiratory disease within a cat shelter. Rather, it led to increases in disease severity and the incidence of detection of FHV-1 DNA in oropharyngeal or conjunctival mucosal swab specimens at certain time points.",
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AU - Bannasch, Mike J.

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