Effects of dietary arachidonate deficiency on the aggregation of cat platelets

Marnie L. MacDonald, Quinton Rogers, James Morris

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

1. Because the cat lacks the ability to synthesize a significant amount of arachidonate from linoleate in the liver, arachidonate is a dietary essential. We studied the effects of essential fatty acid deficiency on the aggregation of cat platelets. 2. Cat platelets aggregated in response to ADP, collagen, arachidonate and epinephrine. 3. Aggregation was impaired in platelets from cats fed arachidonate-deficient diets. 4. Including a source of linoleate in the arachidonate-deficient diet did not improve aggregation. 5. Arachidonate is required in the diet of the cat for normal platelet aggregation.

Original languageEnglish (US)
Pages (from-to)123-126
Number of pages4
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume78
Issue number1
DOIs
StatePublished - Jan 1 1984

Fingerprint

Platelet Aggregation
Cats
Linoleic Acid
Diet
Blood Platelets
Essential Fatty Acids
Adenosine Diphosphate
Epinephrine
Collagen
Liver

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

Cite this

Effects of dietary arachidonate deficiency on the aggregation of cat platelets. / MacDonald, Marnie L.; Rogers, Quinton; Morris, James.

In: Comparative Biochemistry and Physiology. Part C, Comparative, Vol. 78, No. 1, 01.01.1984, p. 123-126.

Research output: Contribution to journalArticle

@article{d7e75b695a784b6ca29c7ba7b1fdaf0d,
title = "Effects of dietary arachidonate deficiency on the aggregation of cat platelets",
abstract = "1. Because the cat lacks the ability to synthesize a significant amount of arachidonate from linoleate in the liver, arachidonate is a dietary essential. We studied the effects of essential fatty acid deficiency on the aggregation of cat platelets. 2. Cat platelets aggregated in response to ADP, collagen, arachidonate and epinephrine. 3. Aggregation was impaired in platelets from cats fed arachidonate-deficient diets. 4. Including a source of linoleate in the arachidonate-deficient diet did not improve aggregation. 5. Arachidonate is required in the diet of the cat for normal platelet aggregation.",
author = "MacDonald, {Marnie L.} and Quinton Rogers and James Morris",
year = "1984",
month = "1",
day = "1",
doi = "10.1016/0742-8413(84)90057-4",
language = "English (US)",
volume = "78",
pages = "123--126",
journal = "Comparative biochemistry and physiology. C: Comparative pharmacology",
issn = "0742-8413",
publisher = "Elsevier BV",
number = "1",

}

TY - JOUR

T1 - Effects of dietary arachidonate deficiency on the aggregation of cat platelets

AU - MacDonald, Marnie L.

AU - Rogers, Quinton

AU - Morris, James

PY - 1984/1/1

Y1 - 1984/1/1

N2 - 1. Because the cat lacks the ability to synthesize a significant amount of arachidonate from linoleate in the liver, arachidonate is a dietary essential. We studied the effects of essential fatty acid deficiency on the aggregation of cat platelets. 2. Cat platelets aggregated in response to ADP, collagen, arachidonate and epinephrine. 3. Aggregation was impaired in platelets from cats fed arachidonate-deficient diets. 4. Including a source of linoleate in the arachidonate-deficient diet did not improve aggregation. 5. Arachidonate is required in the diet of the cat for normal platelet aggregation.

AB - 1. Because the cat lacks the ability to synthesize a significant amount of arachidonate from linoleate in the liver, arachidonate is a dietary essential. We studied the effects of essential fatty acid deficiency on the aggregation of cat platelets. 2. Cat platelets aggregated in response to ADP, collagen, arachidonate and epinephrine. 3. Aggregation was impaired in platelets from cats fed arachidonate-deficient diets. 4. Including a source of linoleate in the arachidonate-deficient diet did not improve aggregation. 5. Arachidonate is required in the diet of the cat for normal platelet aggregation.

UR - http://www.scopus.com/inward/record.url?scp=0021253271&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021253271&partnerID=8YFLogxK

U2 - 10.1016/0742-8413(84)90057-4

DO - 10.1016/0742-8413(84)90057-4

M3 - Article

C2 - 6146457

AN - SCOPUS:0021253271

VL - 78

SP - 123

EP - 126

JO - Comparative biochemistry and physiology. C: Comparative pharmacology

JF - Comparative biochemistry and physiology. C: Comparative pharmacology

SN - 0742-8413

IS - 1

ER -