Effects of cyclic compressive loading on a biodegradable implant

D. Thompson, C. M. Agrawal, K. Athanasiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Mechanical stresses change the mechanical behavior and drug release kinetics of implants. The biodegradable implants made of 50:50 PLA/PGA were subjected to dynamic compressive loading. The implants underwent a volume reduction and became significantly stiffer compared to the unloaded specimens, because the external stresses made the pores in the polymer matrix collapse. The collapse also left a smaller surface area for hydrolysis, thus reducing the rate of molecular degradation.

Original languageEnglish (US)
Title of host publicationTransactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium
Editors Anon
Place of PublicationSt. Louis Park, MN, United States
PublisherSoc for Biomaterials
Pages877
Number of pages1
Volume1
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Thompson, D., Agrawal, C. M., & Athanasiou, K. (1996). Effects of cyclic compressive loading on a biodegradable implant. In Anon (Ed.), Transactions of the Annual Meeting of the Society for Biomaterials in conjunction with the International Biomaterials Symposium (Vol. 1, pp. 877). Soc for Biomaterials.