Effects of contrast media on renal function and subcellular morphology in the dog

Richard W Katzberg, Rufino C. Pabico, Thomas W. Morris, Katsumi Hayakawa, Barbara A. McKenna, Bernard J. Panner, Janine A. Ventur, Harry W. Fischer

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The effects of intravenous contrast media (CM) on renal excretory function and subcellular morphology are examined in this animal investigation. A decrease in GFR (12.0 ±1.6 vs. control 30.2 ± 2.S ml/min) was observed when renal function was evaluated by means of the artero-venous extraction method with Tc99m DTP A and the anticipated inverse relationship to urinary flow (Vml/min) noted. An artifactual increase in GFR (43.S ± 10.0 vs. control 39.1 ± 3.8 ml/min) was observed using the timed urinary clearance of inulin. V(ml/min) increased four-fold (0.6 ± 0.16 control vs. 2.7 ± 0.7 ml/min; P <.05) over the first five minutes after injection of CM. Urine osmolality initially approached isotonicity and then returned toward preinjection values. Osmolal clearance (Cosm) rose 2.5 times (1.4 ± 0.3 control vs. 3.7 ± T.O ml/min; P <.05). The fractional excretion of both Na+ (FENa) and K+ (FEK+) increased. A comparison of urinary osmolality vs. time after injection of CM confirms a nonspecific osmotic effect on tubular (and hence total urine) flow. The hemodynamic effects of CM on the kidney via the 1.v. route reflect a predominant and nonspecific osmotically mediated vasodilation. No significant light or electron microscopic changes were observed. These finding’s suggest that the major renal physiologic actions of hypertonic CM are a nonspecific response to agent osmolality.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalInvestigative Radiology
Issue number1
StatePublished - 1986
Externally publishedYes


  • Contrast medium
  • Renal function
  • Renal hemodynamics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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