Effects of contrast media on renal function and subcellular morphology in the dog

Richard W Katzberg, Rufino C. Pabico, Thomas W. Morris, Katsumi Hayakawa, Barbara A. McKenna, Bernard J. Panner, Janine A. Ventur, Harry W. Fischer

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The effects of intravenous contrast media (CM) on renal excretory function and subcellular morphology are examined in this animal investigation. A decrease in GFR (12.0 ±1.6 vs. control 30.2 ± 2.S ml/min) was observed when renal function was evaluated by means of the artero-venous extraction method with Tc99m DTP A and the anticipated inverse relationship to urinary flow (Vml/min) noted. An artifactual increase in GFR (43.S ± 10.0 vs. control 39.1 ± 3.8 ml/min) was observed using the timed urinary clearance of inulin. V(ml/min) increased four-fold (0.6 ± 0.16 control vs. 2.7 ± 0.7 ml/min; P <.05) over the first five minutes after injection of CM. Urine osmolality initially approached isotonicity and then returned toward preinjection values. Osmolal clearance (Cosm) rose 2.5 times (1.4 ± 0.3 control vs. 3.7 ± T.O ml/min; P <.05). The fractional excretion of both Na+ (FENa) and K+ (FEK+) increased. A comparison of urinary osmolality vs. time after injection of CM confirms a nonspecific osmotic effect on tubular (and hence total urine) flow. The hemodynamic effects of CM on the kidney via the 1.v. route reflect a predominant and nonspecific osmotically mediated vasodilation. No significant light or electron microscopic changes were observed. These finding’s suggest that the major renal physiologic actions of hypertonic CM are a nonspecific response to agent osmolality.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
JournalInvestigative Radiology
Volume21
Issue number1
StatePublished - 1986
Externally publishedYes

Fingerprint

Contrast Media
Dogs
Kidney
Osmolar Concentration
Urine
Injections
Inulin
Vasodilation
Hemodynamics
Electrons
Light

Keywords

  • Contrast medium
  • Renal function
  • Renal hemodynamics

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Katzberg, R. W., Pabico, R. C., Morris, T. W., Hayakawa, K., McKenna, B. A., Panner, B. J., ... Fischer, H. W. (1986). Effects of contrast media on renal function and subcellular morphology in the dog. Investigative Radiology, 21(1), 64-70.

Effects of contrast media on renal function and subcellular morphology in the dog. / Katzberg, Richard W; Pabico, Rufino C.; Morris, Thomas W.; Hayakawa, Katsumi; McKenna, Barbara A.; Panner, Bernard J.; Ventur, Janine A.; Fischer, Harry W.

In: Investigative Radiology, Vol. 21, No. 1, 1986, p. 64-70.

Research output: Contribution to journalArticle

Katzberg, RW, Pabico, RC, Morris, TW, Hayakawa, K, McKenna, BA, Panner, BJ, Ventur, JA & Fischer, HW 1986, 'Effects of contrast media on renal function and subcellular morphology in the dog', Investigative Radiology, vol. 21, no. 1, pp. 64-70.
Katzberg RW, Pabico RC, Morris TW, Hayakawa K, McKenna BA, Panner BJ et al. Effects of contrast media on renal function and subcellular morphology in the dog. Investigative Radiology. 1986;21(1):64-70.
Katzberg, Richard W ; Pabico, Rufino C. ; Morris, Thomas W. ; Hayakawa, Katsumi ; McKenna, Barbara A. ; Panner, Bernard J. ; Ventur, Janine A. ; Fischer, Harry W. / Effects of contrast media on renal function and subcellular morphology in the dog. In: Investigative Radiology. 1986 ; Vol. 21, No. 1. pp. 64-70.
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