Abstract
The effects of intravenous contrast media (CM) on renal excretory function and subcellular morphology are examined in this animal investigation. A decrease in GFR (12.0 ±1.6 vs. control 30.2 ± 2.S ml/min) was observed when renal function was evaluated by means of the artero-venous extraction method with Tc99m DTP A and the anticipated inverse relationship to urinary flow (Vml/min) noted. An artifactual increase in GFR (43.S ± 10.0 vs. control 39.1 ± 3.8 ml/min) was observed using the timed urinary clearance of inulin. V(ml/min) increased four-fold (0.6 ± 0.16 control vs. 2.7 ± 0.7 ml/min; P <.05) over the first five minutes after injection of CM. Urine osmolality initially approached isotonicity and then returned toward preinjection values. Osmolal clearance (Cosm) rose 2.5 times (1.4 ± 0.3 control vs. 3.7 ± T.O ml/min; P <.05). The fractional excretion of both Na+ (FENa) and K+ (FEK+) increased. A comparison of urinary osmolality vs. time after injection of CM confirms a nonspecific osmotic effect on tubular (and hence total urine) flow. The hemodynamic effects of CM on the kidney via the 1.v. route reflect a predominant and nonspecific osmotically mediated vasodilation. No significant light or electron microscopic changes were observed. These finding’s suggest that the major renal physiologic actions of hypertonic CM are a nonspecific response to agent osmolality.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 64-70 |
| Number of pages | 7 |
| Journal | Investigative Radiology |
| Volume | 21 |
| Issue number | 1 |
| State | Published - 1986 |
| Externally published | Yes |
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Keywords
- Contrast medium
- Renal function
- Renal hemodynamics
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Effects of contrast media on renal function and subcellular morphology in the dog. / Katzberg, Richard W; Pabico, Rufino C.; Morris, Thomas W.; Hayakawa, Katsumi; McKenna, Barbara A.; Panner, Bernard J.; Ventur, Janine A.; Fischer, Harry W.
In: Investigative Radiology, Vol. 21, No. 1, 1986, p. 64-70.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of contrast media on renal function and subcellular morphology in the dog
AU - Katzberg, Richard W
AU - Pabico, Rufino C.
AU - Morris, Thomas W.
AU - Hayakawa, Katsumi
AU - McKenna, Barbara A.
AU - Panner, Bernard J.
AU - Ventur, Janine A.
AU - Fischer, Harry W.
PY - 1986
Y1 - 1986
N2 - The effects of intravenous contrast media (CM) on renal excretory function and subcellular morphology are examined in this animal investigation. A decrease in GFR (12.0 ±1.6 vs. control 30.2 ± 2.S ml/min) was observed when renal function was evaluated by means of the artero-venous extraction method with Tc99m DTP A and the anticipated inverse relationship to urinary flow (Vml/min) noted. An artifactual increase in GFR (43.S ± 10.0 vs. control 39.1 ± 3.8 ml/min) was observed using the timed urinary clearance of inulin. V(ml/min) increased four-fold (0.6 ± 0.16 control vs. 2.7 ± 0.7 ml/min; P <.05) over the first five minutes after injection of CM. Urine osmolality initially approached isotonicity and then returned toward preinjection values. Osmolal clearance (Cosm) rose 2.5 times (1.4 ± 0.3 control vs. 3.7 ± T.O ml/min; P <.05). The fractional excretion of both Na+ (FENa) and K+ (FEK+) increased. A comparison of urinary osmolality vs. time after injection of CM confirms a nonspecific osmotic effect on tubular (and hence total urine) flow. The hemodynamic effects of CM on the kidney via the 1.v. route reflect a predominant and nonspecific osmotically mediated vasodilation. No significant light or electron microscopic changes were observed. These finding’s suggest that the major renal physiologic actions of hypertonic CM are a nonspecific response to agent osmolality.
AB - The effects of intravenous contrast media (CM) on renal excretory function and subcellular morphology are examined in this animal investigation. A decrease in GFR (12.0 ±1.6 vs. control 30.2 ± 2.S ml/min) was observed when renal function was evaluated by means of the artero-venous extraction method with Tc99m DTP A and the anticipated inverse relationship to urinary flow (Vml/min) noted. An artifactual increase in GFR (43.S ± 10.0 vs. control 39.1 ± 3.8 ml/min) was observed using the timed urinary clearance of inulin. V(ml/min) increased four-fold (0.6 ± 0.16 control vs. 2.7 ± 0.7 ml/min; P <.05) over the first five minutes after injection of CM. Urine osmolality initially approached isotonicity and then returned toward preinjection values. Osmolal clearance (Cosm) rose 2.5 times (1.4 ± 0.3 control vs. 3.7 ± T.O ml/min; P <.05). The fractional excretion of both Na+ (FENa) and K+ (FEK+) increased. A comparison of urinary osmolality vs. time after injection of CM confirms a nonspecific osmotic effect on tubular (and hence total urine) flow. The hemodynamic effects of CM on the kidney via the 1.v. route reflect a predominant and nonspecific osmotically mediated vasodilation. No significant light or electron microscopic changes were observed. These finding’s suggest that the major renal physiologic actions of hypertonic CM are a nonspecific response to agent osmolality.
KW - Contrast medium
KW - Renal function
KW - Renal hemodynamics
UR - http://www.scopus.com/inward/record.url?scp=0022657637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022657637&partnerID=8YFLogxK
M3 - Article
C2 - 3080383
AN - SCOPUS:0022657637
VL - 21
SP - 64
EP - 70
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 1
ER -