Effects of consuming sugar-sweetened beverages for 2 weeks on 24-h circulating leptin profiles, ad libitum food intake and body weight in young adults

Desiree M. Sigala, Adrianne M. Widaman, Bettina Hieronimus, Marinelle V. Nunez, Vivien Lee, Yanet Benyam, Andrew Bremer, Valentina Medici, Peter J. Havel, Kimber L. Stanhope, Nancy L Keim

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Sugar-sweetened beverage (sugar-SB) consumption is associated with body weight gain. We investigated whether the changes of (∆) circulating leptin contribute to weight gain and ad libitum food intake in young adults consuming sugar-SB for two weeks. In a parallel, double-blinded, intervention study, participants (n = 131; BMI 18–35 kg/m2; 18–40 years) consumed three beverages/day containing aspartame or 25% energy requirement as glucose, fructose, high fructose corn syrup (HFCS) or sucrose (n = 23–28/group). Body weight, ad libitum food intake and 24-h leptin area under the curve (AUC) were assessed at Week 0 and at the end of Week 2. The ∆body weight was not different among groups (p = 0.092), but the increases in subjects consuming HFCS-(p = 0.0008) and glucose-SB (p = 0.018) were significant compared with Week 0. Subjects consuming sucrose-(+14%, p < 0.0015), fructose-(+9%, p = 0.015) and HFCS-SB (+8%, p = 0.017) increased energy intake during the ad libitum food intake trial compared with subjects consuming aspartame-SB (−4%, p = 0.0037, effect of SB). Fructose-SB decreased (−14 ng/mL × 24 h, p = 0.0006) and sucrose-SB increased (+25 ng/mL × 24 h, p = 0.025 vs. Week 0; p = 0.0008 vs. fructose-SB) 24-h leptin AUC. The ∆ad libitum food intake and ∆body weight were not influenced by circulating leptin in young adults consuming sugar-SB for 2 weeks. Studies are needed to determine the mechanisms mediating increased energy intake in subjects consuming sugar-SB.

Original languageEnglish (US)
Article number3893
Pages (from-to)1-17
Number of pages17
JournalNutrients
Volume12
Issue number12
DOIs
StatePublished - Dec 2020

Keywords

  • Aspartame
  • Energy compensation
  • Energy intake
  • Fructose
  • Glucose
  • High fructose corn syrup
  • Leptin
  • Obesity
  • Satiety
  • Sucrose

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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