Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium

J. B. Valdrighi, Neal Fleming, B. K. Smith, G. L. Baker, D. A. White

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalBritish Journal of Anaesthesia
Volume72
Issue number2
DOIs
StatePublished - Feb 1994

Fingerprint

cholinesterase inhibitors
suxamethonium
Succinylcholine
Cholinesterase Inhibitors
Inhibitor
Edrophonium
Pyridostigmine Bromide
neostigmine
Recovery
Neostigmine
Neuromuscular Block
Neuromuscular Blockade
Baseline
Rats
Pentobarbital
Dose
Drugs
Scanning electron microscopy
drugs
Interaction

Keywords

  • Antagonists, neuromuscular block: edrophonium, neostigmine, pyridostigmine
  • Enzymes: cholinesterase, pseudocholinesterase
  • Neuromuscular block: suxamethonium

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine

Cite this

Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium. / Valdrighi, J. B.; Fleming, Neal; Smith, B. K.; Baker, G. L.; White, D. A.

In: British Journal of Anaesthesia, Vol. 72, No. 2, 02.1994, p. 237-239.

Research output: Contribution to journalArticle

Valdrighi, J. B. ; Fleming, Neal ; Smith, B. K. ; Baker, G. L. ; White, D. A. / Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium. In: British Journal of Anaesthesia. 1994 ; Vol. 72, No. 2. pp. 237-239.
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