Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium

J. B. Valdrighi; Neal Fleming; B. K. Smith; G. L. Baker; D. A. White

doi:10.1093/bja/72.2.237

Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium

J. B. Valdrighi, Neal Fleming, B. K. Smith, G. L. Baker, D. A. White

Anesthesiology and Pain Medicine

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.

Original language	English (US)
Pages (from-to)	237-239
Number of pages	3
Journal	British Journal of Anaesthesia
Volume	72
Issue number	2
DOIs	https://doi.org/10.1093/bja/72.2.237
State	Published - Feb 1994

Keywords

Antagonists, neuromuscular block: edrophonium, neostigmine, pyridostigmine
Enzymes: cholinesterase, pseudocholinesterase
Neuromuscular block: suxamethonium

ASJC Scopus subject areas

Statistics, Probability and Uncertainty
Applied Mathematics
Mathematics(all)
Statistics and Probability
Agricultural and Biological Sciences (miscellaneous)
Anesthesiology and Pain Medicine

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title = "Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium",

abstract = "Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.",

keywords = "Antagonists, neuromuscular block: edrophonium, neostigmine, pyridostigmine, Enzymes: cholinesterase, pseudocholinesterase, Neuromuscular block: suxamethonium",

author = "Valdrighi, {J. B.} and Neal Fleming and Smith, {B. K.} and Baker, {G. L.} and White, {D. A.}",

year = "1994",

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AU - Smith, B. K.

AU - Baker, G. L.

AU - White, D. A.

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N2 - Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.

AB - Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.

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