Abstract
Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 237-239 |
| Number of pages | 3 |
| Journal | British Journal of Anaesthesia |
| Volume | 72 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1994 |
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Keywords
- Antagonists, neuromuscular block: edrophonium, neostigmine, pyridostigmine
- Enzymes: cholinesterase, pseudocholinesterase
- Neuromuscular block: suxamethonium
ASJC Scopus subject areas
- Statistics, Probability and Uncertainty
- Applied Mathematics
- Mathematics(all)
- Statistics and Probability
- Agricultural and Biological Sciences (miscellaneous)
- Anesthesiology and Pain Medicine
Cite this
Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium. / Valdrighi, J. B.; Fleming, Neal; Smith, B. K.; Baker, G. L.; White, D. A.
In: British Journal of Anaesthesia, Vol. 72, No. 2, 02.1994, p. 237-239.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium
AU - Valdrighi, J. B.
AU - Fleming, Neal
AU - Smith, B. K.
AU - Baker, G. L.
AU - White, D. A.
PY - 1994/2
Y1 - 1994/2
N2 - Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.
AB - Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.
KW - Antagonists, neuromuscular block: edrophonium, neostigmine, pyridostigmine
KW - Enzymes: cholinesterase, pseudocholinesterase
KW - Neuromuscular block: suxamethonium
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UR - http://www.scopus.com/inward/citedby.url?scp=0028084875&partnerID=8YFLogxK
U2 - 10.1093/bja/72.2.237
DO - 10.1093/bja/72.2.237
M3 - Article
VL - 72
SP - 237
EP - 239
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
SN - 0007-0912
IS - 2
ER -