Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium

J. B. Valdrighi, Neal Fleming, B. K. Smith, G. L. Baker, D. A. White

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Prolonged neuromuscular block occurs when suxamethonium is given after neostigmine or pyridostigmine; however, studies of edrophonium and suxamethonium have yielded conflicting results. We have studied, therefore, interactions between suxamethonium and all three anticholinesterases in rats anaesthetized with pentobarbitone. After recovery from an initial bolus of suxamethonium, saline, edrophonium, pyridostigmine or neostigmine was administered and a second dose of suxamethonium was then given. All three anticholinesterases prolonged the duration of neuromuscular block (90% suppression to 50% twitch recovery) to 127(SEM 9)%, 127(10)% and 138 (11)% of baseline for edrophonium, pyridostigmine and neostigmine, respectively. Recovery index (25% to 75% twitch recovery) was increased also to 125 (9)%; 149 (10%) and 185 (15)% of baseline, respectively for the three drugs.

Original languageEnglish (US)
Pages (from-to)237-239
Number of pages3
JournalBritish Journal of Anaesthesia
Issue number2
StatePublished - Feb 1994


  • Antagonists, neuromuscular block: edrophonium, neostigmine, pyridostigmine
  • Enzymes: cholinesterase, pseudocholinesterase
  • Neuromuscular block: suxamethonium

ASJC Scopus subject areas

  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Mathematics(all)
  • Statistics and Probability
  • Agricultural and Biological Sciences (miscellaneous)
  • Anesthesiology and Pain Medicine


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