Effects of cholinergic agonists on two non-pyramidal cell types in rat hippocampal slices

Laura J. Reece, Philip A Schwartzkroin

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In the hippocampus, pyramidal cells (PCs) are not the only cell type sensitive to cholinergic stimulation. Two non-pyramidal cell types from animals as young as 8 days demonstrated clear, direct responses to application of cholinergic agonists. These cholinergic actions are excitatory, mostly blocked by muscarinic antagonists, and persist under conditions which block synaptic transmission (TTX, low Ca2+/high Mg2+). Cholinergic agonists may affect different conductances in interneurons than in PCs, sometimes resulting in rapid depolarization. Demonstration of direct excitatory cholinergic effects on inhibitory interneurons supports the view that cholinergically-evoked hyperpolarizations in PCs are due to local circuit interactions.

Original languageEnglish (US)
Pages (from-to)115-126
Number of pages12
JournalBrain Research
Volume566
Issue number1-2
DOIs
StatePublished - Dec 6 1991
Externally publishedYes

Fingerprint

Cholinergic Agonists
Pyramidal Cells
Cholinergic Agents
Interneurons
Muscarinic Antagonists
Synaptic Transmission
Hippocampus

Keywords

  • Acetylcholine
  • Hippocampus
  • Interneuron
  • Local circuitry

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Effects of cholinergic agonists on two non-pyramidal cell types in rat hippocampal slices. / Reece, Laura J.; Schwartzkroin, Philip A.

In: Brain Research, Vol. 566, No. 1-2, 06.12.1991, p. 115-126.

Research output: Contribution to journalArticle

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