Effects of catecholamines and ammonia on plasma and brain amino acids in dogs

D. R. Stormbeck, D. Harrold, Quinton Rogers

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Investigations were made on the effects of catecholamine (Cat) infusions with and without ammonia (NH3) on plasma and brain amino acids (AA) and brain neurotransmitters in dogs. Groups of four dogs were infused for 5 h with epinephrine (E), epinephrine + norepinephrine (E + NE), epinephrine + norepinephrine with NH3 during h4 and 5 (E + NE + NH3), epinephrine + norepinephrine + tryptophan with NH3 during h 4 and 5 (T + E + NE + NH3), or saline (C). Cat decreased (P < 0.05) plasma Gly, Thr, Lys, Pro, Val, Ser, Arg, Leu, Trp, Phe, Asn, Tyr, Met, Ile, Cit, and Asp. The decreases at h 3 for all were to a mean of 45% of 0 h and were associated with no changes in plasma insulin or glucagon. Cat increased plasma Tau and Orn. Of the most abundant brain AA (82% of total), E + NE + NH3 had no effect (GABA, Asp, Gly, Ala, p-ethanolamine) or increased (Glu, Gln, Tau) brain levels. These AA were unchanged by Cat alone. Of the remaining brain AA, most were decreased by Cat (7 of 16, P < 0.05) and E + NE + NH3 increased brain Trp but had no effect on brain serotonin, 5-hydroxyindoleacetic acid, or NE. Cat changed plasma AA in a way similar to changes produced by NH3 infusion and seen with hepatic insufficiency due to portacaval shunts and nitrosamine-induced pathology. Cat reduced brain AA levels, and this was partially restored by NH3.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Volume10
Issue number2
StatePublished - Jan 1 1984

Fingerprint

Ammonia
Epinephrine
Catecholamines
Norepinephrine
Dogs
Amino Acids
Brain
Surgical Portacaval Shunt
Hepatic Insufficiency
Nitrosamines
Hydroxyindoleacetic Acid
Ethanolamine
Viperidae
Glucagon
Tryptophan
gamma-Aminobutyric Acid
Neurotransmitter Agents
Serotonin
Insulin
Pathology

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)

Cite this

Effects of catecholamines and ammonia on plasma and brain amino acids in dogs. / Stormbeck, D. R.; Harrold, D.; Rogers, Quinton.

In: American Journal of Physiology - Endocrinology and Metabolism, Vol. 10, No. 2, 01.01.1984.

Research output: Contribution to journalArticle

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