Effects of cardiac output on 18O2 lung diffusion in normal resting man

Henry Gong, Cornelis J. Kurpershoek, Delbert H. Meyer, Carroll E Cross

Research output: Contribution to journalArticle

Abstract

Single-breath resting diffusing capacities for CO (DlCO) and 18O2 (DlO2 ) were measured simultaneously with pulmonary capillary blood flow (Q̇c) in nine normal males at hypoxic alveolar O2 tensions (PO2 42 torr). DlCO (54 ± 5 ml stpd . min-1 . torr-1) was significantly higher than DlO2 (33 ± 11 ml stpd ± min-1 . torr-1). Extrapolation of the linear regressions between DlCO and DlO2 and cardiac output (range 4860 to 12,270 ml . min-1) suggest that DlO2 approximates DlCO at cardiac outputs of 18 L . min-1 in our subjects. No significant differences between the previously measured diffusing capacity for 18O16O (Hyde et al., 1966) and the present value for 18O18O was found. The discrepancy between the measured DlO2 and the predicted DlO2 calculated indirectly from the DlCO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/Q̇c) probably accounts for this discrepancy. DL/Q̇c inhomogeneity, along with right-to-left shunts and V̇a/Qc inhomogeneities, must be taken into account when arterial-alveolar O2 gradients are evaluated.

Original languageEnglish (US)
Pages (from-to)313-326
Number of pages14
JournalRespiration Physiology
Volume16
Issue number3
DOIs
StatePublished - 1972

Fingerprint

Cardiac Output
Lung
Carbon Monoxide
Linear Models

Keywords

  • Diffusion/perfusion ratio
  • Pulmonary capillary blood flow
  • Pulmonary capillary blood volume
  • Pulmonary diffusing capacity

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Effects of cardiac output on 18O2 lung diffusion in normal resting man. / Gong, Henry; Kurpershoek, Cornelis J.; Meyer, Delbert H.; Cross, Carroll E.

In: Respiration Physiology, Vol. 16, No. 3, 1972, p. 313-326.

Research output: Contribution to journalArticle

Gong, Henry ; Kurpershoek, Cornelis J. ; Meyer, Delbert H. ; Cross, Carroll E. / Effects of cardiac output on 18O2 lung diffusion in normal resting man. In: Respiration Physiology. 1972 ; Vol. 16, No. 3. pp. 313-326.
@article{93381f05b0b540c6a758da7f73431505,
title = "Effects of cardiac output on 18O2 lung diffusion in normal resting man",
abstract = "Single-breath resting diffusing capacities for CO (DlCO) and 18O2 (DlO2 ) were measured simultaneously with pulmonary capillary blood flow (Q̇c) in nine normal males at hypoxic alveolar O2 tensions (PO2 42 torr). DlCO (54 ± 5 ml stpd . min-1 . torr-1) was significantly higher than DlO2 (33 ± 11 ml stpd ± min-1 . torr-1). Extrapolation of the linear regressions between DlCO and DlO2 and cardiac output (range 4860 to 12,270 ml . min-1) suggest that DlO2 approximates DlCO at cardiac outputs of 18 L . min-1 in our subjects. No significant differences between the previously measured diffusing capacity for 18O16O (Hyde et al., 1966) and the present value for 18O18O was found. The discrepancy between the measured DlO2 and the predicted DlO2 calculated indirectly from the DlCO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/Q̇c) probably accounts for this discrepancy. DL/Q̇c inhomogeneity, along with right-to-left shunts and V̇a/Qc inhomogeneities, must be taken into account when arterial-alveolar O2 gradients are evaluated.",
keywords = "Diffusion/perfusion ratio, Pulmonary capillary blood flow, Pulmonary capillary blood volume, Pulmonary diffusing capacity",
author = "Henry Gong and Kurpershoek, {Cornelis J.} and Meyer, {Delbert H.} and Cross, {Carroll E}",
year = "1972",
doi = "10.1016/0034-5687(72)90061-8",
language = "English (US)",
volume = "16",
pages = "313--326",
journal = "Respiratory Physiology and Neurobiology",
issn = "1569-9048",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Effects of cardiac output on 18O2 lung diffusion in normal resting man

AU - Gong, Henry

AU - Kurpershoek, Cornelis J.

AU - Meyer, Delbert H.

AU - Cross, Carroll E

PY - 1972

Y1 - 1972

N2 - Single-breath resting diffusing capacities for CO (DlCO) and 18O2 (DlO2 ) were measured simultaneously with pulmonary capillary blood flow (Q̇c) in nine normal males at hypoxic alveolar O2 tensions (PO2 42 torr). DlCO (54 ± 5 ml stpd . min-1 . torr-1) was significantly higher than DlO2 (33 ± 11 ml stpd ± min-1 . torr-1). Extrapolation of the linear regressions between DlCO and DlO2 and cardiac output (range 4860 to 12,270 ml . min-1) suggest that DlO2 approximates DlCO at cardiac outputs of 18 L . min-1 in our subjects. No significant differences between the previously measured diffusing capacity for 18O16O (Hyde et al., 1966) and the present value for 18O18O was found. The discrepancy between the measured DlO2 and the predicted DlO2 calculated indirectly from the DlCO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/Q̇c) probably accounts for this discrepancy. DL/Q̇c inhomogeneity, along with right-to-left shunts and V̇a/Qc inhomogeneities, must be taken into account when arterial-alveolar O2 gradients are evaluated.

AB - Single-breath resting diffusing capacities for CO (DlCO) and 18O2 (DlO2 ) were measured simultaneously with pulmonary capillary blood flow (Q̇c) in nine normal males at hypoxic alveolar O2 tensions (PO2 42 torr). DlCO (54 ± 5 ml stpd . min-1 . torr-1) was significantly higher than DlO2 (33 ± 11 ml stpd ± min-1 . torr-1). Extrapolation of the linear regressions between DlCO and DlO2 and cardiac output (range 4860 to 12,270 ml . min-1) suggest that DlO2 approximates DlCO at cardiac outputs of 18 L . min-1 in our subjects. No significant differences between the previously measured diffusing capacity for 18O16O (Hyde et al., 1966) and the present value for 18O18O was found. The discrepancy between the measured DlO2 and the predicted DlO2 calculated indirectly from the DlCO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/Q̇c) probably accounts for this discrepancy. DL/Q̇c inhomogeneity, along with right-to-left shunts and V̇a/Qc inhomogeneities, must be taken into account when arterial-alveolar O2 gradients are evaluated.

KW - Diffusion/perfusion ratio

KW - Pulmonary capillary blood flow

KW - Pulmonary capillary blood volume

KW - Pulmonary diffusing capacity

UR - http://www.scopus.com/inward/record.url?scp=0015458693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015458693&partnerID=8YFLogxK

U2 - 10.1016/0034-5687(72)90061-8

DO - 10.1016/0034-5687(72)90061-8

M3 - Article

C2 - 4644058

AN - SCOPUS:0015458693

VL - 16

SP - 313

EP - 326

JO - Respiratory Physiology and Neurobiology

JF - Respiratory Physiology and Neurobiology

SN - 1569-9048

IS - 3

ER -