Effects of cardiac output on 18O2 lung diffusion in normal resting man

Henry Gong; Cornelis J. Kurpershoek; Delbert H. Meyer; Carroll E Cross

doi:10.1016/0034-5687(72)90061-8

Effects of cardiac output on ¹⁸O₂ lung diffusion in normal resting man

Henry Gong, Cornelis J. Kurpershoek, Delbert H. Meyer, Carroll E Cross

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article

Abstract

Single-breath resting diffusing capacities for CO (Dl_CO) and ¹⁸O₂ (Dl_O₂) were measured simultaneously with pulmonary capillary blood flow (Q̇c) in nine normal males at hypoxic alveolar O₂ tensions (P_O₂ 42 torr). Dl_CO (54 ± 5 ml stpd . min^-1 . torr^-1) was significantly higher than Dl_O₂ (33 ± 11 ml stpd ± min^-1 . torr^-1). Extrapolation of the linear regressions between Dl_CO and Dl_O₂ and cardiac output (range 4860 to 12,270 ml . min^-1) suggest that Dl_O₂ approximates Dl_CO at cardiac outputs of 18 L . min^-1 in our subjects. No significant differences between the previously measured diffusing capacity for ¹⁸O¹⁶O (Hyde et al., 1966) and the present value for ¹⁸O¹⁸O was found. The discrepancy between the measured Dl_O₂ and the predicted Dl_O₂ calculated indirectly from the Dl_CO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/Q̇c) probably accounts for this discrepancy. DL/Q̇c inhomogeneity, along with right-to-left shunts and V̇a/Qc inhomogeneities, must be taken into account when arterial-alveolar O₂ gradients are evaluated.

Original language	English (US)
Pages (from-to)	313-326
Number of pages	14
Journal	Respiration Physiology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(72)90061-8
State	Published - 1972

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Keywords

Diffusion/perfusion ratio
Pulmonary capillary blood flow
Pulmonary capillary blood volume
Pulmonary diffusing capacity

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

Cite this

Gong, H., Kurpershoek, C. J., Meyer, D. H., & Cross, C. E. (1972). Effects of cardiac output on ¹⁸O₂ lung diffusion in normal resting man. Respiration Physiology, 16(3), 313-326. https://doi.org/10.1016/0034-5687(72)90061-8

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title = "Effects of cardiac output on 18O2 lung diffusion in normal resting man",

abstract = "Single-breath resting diffusing capacities for CO (DlCO) and 18O2 (DlO2 ) were measured simultaneously with pulmonary capillary blood flow ({\.Q}c) in nine normal males at hypoxic alveolar O2 tensions (PO2 42 torr). DlCO (54 ± 5 ml stpd . min-1 . torr-1) was significantly higher than DlO2 (33 ± 11 ml stpd ± min-1 . torr-1). Extrapolation of the linear regressions between DlCO and DlO2 and cardiac output (range 4860 to 12,270 ml . min-1) suggest that DlO2 approximates DlCO at cardiac outputs of 18 L . min-1 in our subjects. No significant differences between the previously measured diffusing capacity for 18O16O (Hyde et al., 1966) and the present value for 18O18O was found. The discrepancy between the measured DlO2 and the predicted DlO2 calculated indirectly from the DlCO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/{\.Q}c) probably accounts for this discrepancy. DL/{\.Q}c inhomogeneity, along with right-to-left shunts and {\.V}a/Qc inhomogeneities, must be taken into account when arterial-alveolar O2 gradients are evaluated.",

keywords = "Diffusion/perfusion ratio, Pulmonary capillary blood flow, Pulmonary capillary blood volume, Pulmonary diffusing capacity",

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N2 - Single-breath resting diffusing capacities for CO (DlCO) and 18O2 (DlO2 ) were measured simultaneously with pulmonary capillary blood flow (Q̇c) in nine normal males at hypoxic alveolar O2 tensions (PO2 42 torr). DlCO (54 ± 5 ml stpd . min-1 . torr-1) was significantly higher than DlO2 (33 ± 11 ml stpd ± min-1 . torr-1). Extrapolation of the linear regressions between DlCO and DlO2 and cardiac output (range 4860 to 12,270 ml . min-1) suggest that DlO2 approximates DlCO at cardiac outputs of 18 L . min-1 in our subjects. No significant differences between the previously measured diffusing capacity for 18O16O (Hyde et al., 1966) and the present value for 18O18O was found. The discrepancy between the measured DlO2 and the predicted DlO2 calculated indirectly from the DlCO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/Q̇c) probably accounts for this discrepancy. DL/Q̇c inhomogeneity, along with right-to-left shunts and V̇a/Qc inhomogeneities, must be taken into account when arterial-alveolar O2 gradients are evaluated.

AB - Single-breath resting diffusing capacities for CO (DlCO) and 18O2 (DlO2 ) were measured simultaneously with pulmonary capillary blood flow (Q̇c) in nine normal males at hypoxic alveolar O2 tensions (PO2 42 torr). DlCO (54 ± 5 ml stpd . min-1 . torr-1) was significantly higher than DlO2 (33 ± 11 ml stpd ± min-1 . torr-1). Extrapolation of the linear regressions between DlCO and DlO2 and cardiac output (range 4860 to 12,270 ml . min-1) suggest that DlO2 approximates DlCO at cardiac outputs of 18 L . min-1 in our subjects. No significant differences between the previously measured diffusing capacity for 18O16O (Hyde et al., 1966) and the present value for 18O18O was found. The discrepancy between the measured DlO2 and the predicted DlO2 calculated indirectly from the DlCO is confirmed. Inhomogeneity of pulmonary capillary diffusing surface area to capillary blood flow (Dl/Q̇c) probably accounts for this discrepancy. DL/Q̇c inhomogeneity, along with right-to-left shunts and V̇a/Qc inhomogeneities, must be taken into account when arterial-alveolar O2 gradients are evaluated.

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10.1016/0034-5687(72)90061-8