Effects of calorie restriction on life span of microorganisms

Craig Skinner, Su Ju Lin

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Calorie restriction (CR) in microorganisms such as budding and fission yeasts has a robust and welldocumented impact on longevity. In order to efficiently utilize the limited energy during CR, these organisms shift from primarily fermentative metabolism to mitochondrial respiration. Respiration activates certain conserved longevity factors such as sirtuins and is associated with widespread physiological changes that contribute to increased survival. However, the importance of respiration during CR-mediated longevity has remained controversial. The emergence of several novel metabolically distinct microbial models for longevity has enabled CR to be studied from new perspectives. The majority of CR and life span studies have been conducted in the primarily fermentative Crabtree-positive yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, but studies in primarily respiratory Crabtree-negative yeast and obligate aerobes can offer complementary insight into the more complex mammalian response to CR. Not only are microorganisms helping characterize a conserved cellular mechanism for CR-mediated longevity, but they can also directly impact mammalian metabolism as part of the natural gut flora. Here, we discuss the contributions of microorganisms to our knowledge of CR and longevity at the level of both the cell and the organism.

Original languageEnglish (US)
Pages (from-to)817-828
Number of pages12
JournalApplied Microbiology and Biotechnology
Volume88
Issue number4
DOIs
StatePublished - Oct 2010

Fingerprint

Respiration
Schizosaccharomyces
Yeasts
Sirtuins
Saccharomycetales
Saccharomyces cerevisiae
Gastrointestinal Microbiome

Keywords

  • Aging
  • Calorie restriction
  • Life span
  • Metabolism
  • Microorganisms
  • Mitochondrial respiration

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

Cite this

Effects of calorie restriction on life span of microorganisms. / Skinner, Craig; Lin, Su Ju.

In: Applied Microbiology and Biotechnology, Vol. 88, No. 4, 10.2010, p. 817-828.

Research output: Contribution to journalArticle

Skinner, Craig ; Lin, Su Ju. / Effects of calorie restriction on life span of microorganisms. In: Applied Microbiology and Biotechnology. 2010 ; Vol. 88, No. 4. pp. 817-828.
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