Effects of calcium channel activators on the response of rabbit aortic rings to alpha1-receptor agonists: Evidence for two modes of action

M. Babich, B. T. Butler, M. T. Piascik

Research output: Contribution to journalArticle

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Abstract

The interaction between activators of the calcium channel and the α1-adrenoceptor has been studied in isolated rabbit aortic rings. The data obtained in these investigations are not consistent with the idea of a homogenous population of α1-receptors which trigger contraction via a single pathway. Our results suggest that calcium channel activators reveal two modes of spasmogenic action for α1-adrenoceptor agonists. Furthermore, we have shown that there may be multiple drug recognition sites on the α1-receptor.

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalPharmacology
Volume39
Issue number3
StatePublished - 1989
Externally publishedYes

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ASJC Scopus subject areas

  • Pharmacology

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