Effects of bovine α-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants

Wolfram M. Brück, Michele Redgrave, Kieran M. Tuohy, Bo Lönnerdal, Gitte Graverholt, Olle Hernell, Glenn R. Gibson

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

OBJECTIVE: Certain milk factors may promote the growth of a host-friendly gastrointestinal microbiota, for example, one that is predominated by bifidobacteria, a perceived health-promoting genus. This may explain why breast-fed infants experience fewer intestinal infections than their formula-fed counterparts who are believed to have a more diverse microbiota, which is similar to that of adults. The effects of formulas supplemented with 2 such ingredients from bovine milk, α-lactalbumin (α-lac) and casein glycomacropeptide (GMP), on gut flora were investigated in this study. PATIENTS AND METHODS: Six-week-old (4-8 wk), healthy term infants were randomised to a standard infant formula or 1 of 2 test formulae enriched in α-lac with higher or lower GMP until 6 months. Faecal bacteriology was determined by the culture-independent procedure fluorescence in situ hybridisation. RESULTS: There was a large fluctuation of bacterial counts within groups with no statistically significant differences between groups. Although all groups showed a predominance of bifidobacteria, breast-fed infants had a small temporary increase in counts. Other bacterial levels varied in formula-fed groups, which overall showed an adult-like faecal microflora. CONCLUSIONS: It can be speculated that a prebiotic effect for α-lac and GMP is achieved only with low starting populations of beneficial microbiota (eg, infants not initially breast-fed.

Original languageEnglish (US)
Pages (from-to)673-679
Number of pages7
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume43
Issue number5
StatePublished - Nov 2006

Fingerprint

Lactalbumin
Infant Formula
lactalbumin
Microbiota
infant formulas
Caseins
breasts
casein
feed formulation
Bifidobacterium
Breast
cattle
milk
health promotion
Milk
bacteriology
prebiotics
fluorescence in situ hybridization
intestinal microorganisms
Prebiotics

Keywords

  • Alpha-lactalbumin
  • Casein glycomacropeptide
  • Fluorescence in situ hybridization
  • Human trials
  • Infant nutrition

ASJC Scopus subject areas

  • Gastroenterology
  • Histology
  • Medicine (miscellaneous)
  • Food Science
  • Pediatrics, Perinatology, and Child Health

Cite this

Brück, W. M., Redgrave, M., Tuohy, K. M., Lönnerdal, B., Graverholt, G., Hernell, O., & Gibson, G. R. (2006). Effects of bovine α-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants. Journal of Pediatric Gastroenterology and Nutrition, 43(5), 673-679.

Effects of bovine α-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants. / Brück, Wolfram M.; Redgrave, Michele; Tuohy, Kieran M.; Lönnerdal, Bo; Graverholt, Gitte; Hernell, Olle; Gibson, Glenn R.

In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 43, No. 5, 11.2006, p. 673-679.

Research output: Contribution to journalArticle

Brück, WM, Redgrave, M, Tuohy, KM, Lönnerdal, B, Graverholt, G, Hernell, O & Gibson, GR 2006, 'Effects of bovine α-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants', Journal of Pediatric Gastroenterology and Nutrition, vol. 43, no. 5, pp. 673-679.
Brück, Wolfram M. ; Redgrave, Michele ; Tuohy, Kieran M. ; Lönnerdal, Bo ; Graverholt, Gitte ; Hernell, Olle ; Gibson, Glenn R. / Effects of bovine α-lactalbumin and casein glycomacropeptide-enriched infant formulae on faecal microbiota in healthy term infants. In: Journal of Pediatric Gastroenterology and Nutrition. 2006 ; Vol. 43, No. 5. pp. 673-679.
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