Effects of angiotensin converting enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon

Stephen R. Hanson, Jerry S Powell, Thomas Dodson, Alan Lumsden, Andrew B. Kelly, Johanna S. Anderson, Alexander W. Clowes, Laurence A. Harker

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

To determine the importance of angiotensin converting enzyme (ACE) activity in the development of arterial proliferative lesions in a primate model, the response to vascular injury was studied in five baboons treated with oral cilazapril (20 mg/kg/day) and in five untreated control animals. Each animal underwent three procedures: 1) carotid artery endarterectomy, 2) balloon catheter deendothelialization of the superficial femoral artery, and 3) surgical placement of bilateral aorto-iliac expanded polytetrafluoroethylene (Gore-Tex) vascular grafts. Cilazapril therapy was initiated 1 week preoperatively and continued throughout the study interval. At 1 and 3 weeks postoperatively, plasma ACE activity was inhibited by more than 96% versus control values. After animals were killed at 3 months, injured vessel and graft segments were evaluated morphometrically. Although the response between animals was variable, average cross-sectional areas of neointima did not differ between the cilazapril-treated and control groups at sites of carotid endarterectomy (0.26±0.12 versus 0.34±0.17 mm2, respectively; p>0.5), femoral artery ballooning (0.15±0.08 versus 0.11±0.01 mm2;p>0.5), or at graft anastomoses (1.86±0.50 versus 1.72±0.50 mm2;p>0.5). Thus, cilazapril did not reduce intimai thickening over 3 months in these primate arterial injury models. However, a possible beneficial effect of cilazapril, which might be apparent at earlier time points or with larger animal groups, cannot be excluded.

Original languageEnglish (US)
JournalHypertension
Volume18
Issue number4 SUPPL.
StatePublished - 1991
Externally publishedYes

Fingerprint

Cilazapril
Tunica Intima
Papio
Peptidyl-Dipeptidase A
Hyperplasia
Blood Vessels
Arteries
Transplants
Carotid Endarterectomy
Femoral Artery
Primates
Neointima
Vascular System Injuries
Polytetrafluoroethylene
Carotid Arteries
Catheters
Control Groups
Wounds and Injuries

Keywords

  • Angiotensin converting enzyme inhibitors
  • Hyperplasia
  • Primate studies

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Hanson, S. R., Powell, J. S., Dodson, T., Lumsden, A., Kelly, A. B., Anderson, J. S., ... Harker, L. A. (1991). Effects of angiotensin converting enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon. Hypertension, 18(4 SUPPL.).

Effects of angiotensin converting enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon. / Hanson, Stephen R.; Powell, Jerry S; Dodson, Thomas; Lumsden, Alan; Kelly, Andrew B.; Anderson, Johanna S.; Clowes, Alexander W.; Harker, Laurence A.

In: Hypertension, Vol. 18, No. 4 SUPPL., 1991.

Research output: Contribution to journalArticle

Hanson, SR, Powell, JS, Dodson, T, Lumsden, A, Kelly, AB, Anderson, JS, Clowes, AW & Harker, LA 1991, 'Effects of angiotensin converting enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon', Hypertension, vol. 18, no. 4 SUPPL..
Hanson, Stephen R. ; Powell, Jerry S ; Dodson, Thomas ; Lumsden, Alan ; Kelly, Andrew B. ; Anderson, Johanna S. ; Clowes, Alexander W. ; Harker, Laurence A. / Effects of angiotensin converting enzyme inhibition with cilazapril on intimal hyperplasia in injured arteries and vascular grafts in the baboon. In: Hypertension. 1991 ; Vol. 18, No. 4 SUPPL.
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